Waist circumference provides an indication of numerous cardiometabolic risk factors in adults with cerebral palsy.
Item Type:Journal Article
Citation:Ryan JM, Crowley VE, Hensey O, McGahey A, Gormley J., Waist circumference provides an indication of numerous cardiometabolic risk factors in adults with cerebral palsy., Archives of Physical Medicine and Rehabilitation, 95, 8, 2014, 1540 - 1546
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OBJECTIVE: To report the prevalence of cardiometabolic risk factors in a cohort of adults with cerebral palsy (CP) and to investigate the ability of anthropometric measures to predict these factors. DESIGN: Cross-sectional study. SETTING: Testing took place in a laboratory setting. PARTICIPANTS: Adults with CP (N=55; mean age, 37.5±13.3 y; Gross Motor Function Classification System levels, I-V) participated in this study. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, glucose, insulin, and C-reactive protein levels were measured from a fasting venous blood sample. Insulin resistance was calculated using the Homeostasis Model Assessment (HOMA-IR) index. Blood pressure, body mass index (BMI), waist circumference (WC), waist-hip ratio, and waist-height ratio were also measured. The metabolic syndrome (MetS) was defined according to the 2009 Joint Interim Statement. RESULTS: The prevalence of the MetS was 20.5% in ambulatory adults and 28.6% in nonambulatory adults. BMI was associated with HOMA-IR only (β=.451; P<.01). WC was associated with HOMA-IR (β=.480; P<.01), triglycerides (β=.450; P<.01), and systolic blood pressure (β=.352; P<.05). Receiver operating characteristic curve analysis revealed that WC provided the best indication of hypertensive blood pressure, dyslipidemia, HOMA-IR, and the presence of multiple risk factors (area under the curve, .713-.763). CONCLUSIONS: A high prevalence of the MetS was observed in this relatively young sample of adults with CP. WC was a better indicator of a number of risk factors than was BMI and presents as a clinically useful method of screening for cardiometabolic risk among adults with CP.
Author: GORMLEY, JOHN
Type of material:Journal Article
Series/Report no:Archives of Physical Medicine and Rehabilitation
Availability:Full text available
Keywords:Body Mss Index