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dc.contributor.authorZGAGA, LINAen
dc.contributor.authorLOPEZ, LORNAen
dc.date.accessioned2016-01-06T15:24:25Z
dc.date.available2016-01-06T15:24:25Z
dc.date.issued2014en
dc.date.submitted2014en
dc.identifier.citationLoth DW, Artigas MS, Gharib SA, Wain LV, Franceschini N, Koch B, Pottinger TD, Smith AV, Duan Q, Oldmeadow C, ... Zgaga L, et al., Genome-wide association analysis identifies six new loci associated with forced vital capacity., Nature Genetics, 47, 7, 2014, 669-77en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/75431
dc.descriptionPUBLISHEDen
dc.description.abstractForced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung volume and is used to diagnose and monitor lung diseases. We performed genome-wide association study meta-analysis of FVC in 52,253 individuals from 26 studies and followed up the top associations in 32,917 additional individuals of European ancestry. We found six new regions associated at genome-wide significance (P < 5 × 10−8) with FVC in or near EFEMP1, BMP6, MIR129-2–HSD17B12, PRDM11, WWOX and KCNJ2. Two loci previously associated with spirometric measures (GSTCD and PTCH1) were related to FVC. Newly implicated regions were followed up in samples from African-American, Korean, Chinese and Hispanic individuals. We detected transcripts for all six newly implicated genes in human lung tissue. The new loci may inform mechanisms involved in lung development and the pathogenesis of restrictive lung disease.en
dc.format.extent669-77en
dc.language.isoenen
dc.relation.ispartofseriesNature Geneticsen
dc.relation.ispartofseries47en
dc.relation.ispartofseries7en
dc.rightsYen
dc.subjectgeneticsen
dc.titleGenome-wide association analysis identifies six new loci associated with forced vital capacity.en
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/zgagalen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/halihanlen
dc.identifier.rssinternalid95541en
dc.identifier.doihttp://dx.doi.org/10.1038/ng.3011.en
dc.rights.ecaccessrightsopenAccess
dc.identifier.orcid_id0000-0003-4089-9703en


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