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dc.contributor.authorO'Farrelly, Clionaen
dc.contributor.authorMok, Kennethen
dc.contributor.authorLavelle, Edwarden
dc.contributor.authorLynch, Lydiaen
dc.date.accessioned2015-12-14T15:51:17Z
dc.date.available2015-12-14T15:51:17Z
dc.date.issued2014en
dc.date.submitted2014en
dc.identifier.citationTynan, GA, Hearnden, CH, Oleszycka, E, Lyons, CL, Coutts, G, O'Connell, J, Corrigan, MA, Lynch, L, Campbell, M, Callanan, JJ, Mok, KH, Geoghegan, J, O'Farrelly, C, Allan, SM, Roche, HM, O'Shea, DB, Lavelle, EC, Endogenous Oils Derived From Human Adipocytes Are Potent Adjuvants That Promote IL-1 alpha-Dependent Inflammation, Diabetes, 63, 6, 2014, 2037-2050en
dc.identifier.issn0012-1797en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/75323
dc.descriptionPUBLISHEDen
dc.description.abstractObesity is characterized by chronic inflammation associated with neutrophil and M1 macrophage infiltration into white adipose tissue. However, the mechanisms underlying this process remain largely unknown. Based on the ability of oil-based adjuvants to induce immune responses, we hypothesized that endogenous oils derived from necrotic adipocytes may function as an immunological "danger signal." Here we show that endogenous oils of human origin are potent adjuvants, enhancing antibody responses to a level comparable to Freund's incomplete adjuvant. The endogenous oils were capable of promoting interleukin (IL)-1α-dependent recruitment of neutrophils and M1-like macrophages, while simultaneously diminishing M2-like macrophages. We found that endogenous oils from subcutaneous and omental adipocytes, and from healthy and unhealthy obese individuals, promoted comparable inflammatory responses. Furthermore, we also confirmed that white adipocytes in visceral fat of metabolically unhealthy obese (MUO) individuals are significantly larger than those in metabolically healthy obese individuals. Since adipocyte size is positively correlated with adipocyte death, we propose that endogenous oils have a higher propensity to be released from hypertrophied visceral fat in MUO individuals and that this is the key factor in driving inflammation. In summary, this study shows that adipocytes contain a potent oil adjuvant which drives IL-1α-dependent proinflammatory responses in vivo.en
dc.format.extent2037-2050en
dc.relation.ispartofseriesDiabetesen
dc.relation.ispartofseries63en
dc.relation.ispartofseries6en
dc.rightsYen
dc.subjectdiabetesen
dc.titleEndogenous Oils Derived From Human Adipocytes Are Potent Adjuvants That Promote IL-1 alpha-Dependent Inflammationen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/ofarreclen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/lavelleeen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/lynchl3en
dc.identifier.peoplefinderurlhttp://people.tcd.ie/mok1en
dc.identifier.rssinternalid95699en
dc.identifier.doihttp://dx.doi.org/10.2337/db13-1476en
dc.rights.ecaccessrightsopenAccess


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