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dc.contributor.authorSENGE, MATHIAS
dc.date.accessioned2015-12-14T12:00:33Z
dc.date.available2015-12-14T12:00:33Z
dc.date.issued2015
dc.date.submitted2015en
dc.identifier.citationWieczorek, S.; Schwaar, T.; Senge, M. O.; Börner, H. G., Specific Drug Formulation Additives: Revealing the Impact of Architecture and Block Length Ratio, Biomacromolecules, 16, 2015, 3308 3312en
dc.identifier.otherY
dc.identifier.urihttp://hdl.handle.net/2262/75308
dc.descriptionPUBLISHEDen
dc.description.abstractCombining poly(ethylene glycol) (PEG) with sequence-defined peptides in PEG-peptide conjugates offers opportunities to realize next-generation drug formulation additives for overcoming undesired pharmacological profiles of difficult small molecule drugs. The tailored peptide segments provide sequence-specific, noncovalent drug binding, and the hydrophilic PEG block renders the complexes water soluble. On the basis of a peptide sequence known to bind the photosensitizer m-tetra(hydroxyphenyl)chlorin (m-THPC) for photodynamic cancer therapy, a set of different conjugate architectures is synthesized and studied. Variations in PEG block length and amplification of the peptidic binding domain of PEG-peptide conjugates are used to fine tune critical parameters for hosting m-THPC, such as drug payload capacities, aggregation sizes, and drug release and activation kinetics.en
dc.format.extent3308 3312en
dc.language.isoenen
dc.relation.ispartofseriesBiomacromolecules;
dc.relation.ispartofseries16;
dc.rightsYen
dc.titleSpecific Drug Formulation Additives: Revealing the Impact of Architecture and Block Length Ratioen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/sengem
dc.identifier.rssinternalid109059
dc.identifier.doi10.1021/acs.biomac.5b00961
dc.rights.ecaccessrightsopenAccess
dc.subject.TCDThemeCanceren


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