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dc.contributor.authorSCANLAN, EOINen
dc.contributor.authorGUNNLAUGSSON, THORFINNURen
dc.contributor.authorSCANLAN, EOINen
dc.contributor.authorGUNNLAUGSSON, THORFINNURen
dc.date.accessioned2015-12-09T11:51:00Z
dc.date.available2015-12-09T11:51:00Z
dc.date.created2015en
dc.date.issued2015en
dc.date.submitted2015en
dc.identifier.citationBurke H.M, Gunnlaugsson T, Scanlan E.M, Recent advances in the development of synthetic chemical probes for glycosidase enzymes, Chemical Communications, 51, 53, 2015, 10576 - 10588en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/75185
dc.descriptionPUBLISHEDen
dc.descriptionExport Date: 23 July 2015en
dc.description.abstractThe emergence of synthetic glycoconjugates as chemical probes for the detection of glycosidase enzymes has resulted in the development of a range of useful chemical tools with applications in glycobiology, biotechnology, medical and industrial research. Critical to the function of these probes is the preparation of substrates containing a glycosidic linkage that when activated by a specific enzyme or group of enzymes, irreversibly releases a reporter molecule that can be detected. Starting from the earliest examples of colourimetric probes, increasingly sensitive and sophisticated substrates have been reported. In this review we present an overview of the recent advances in this field, covering an array of strategies including chromogenic and fluorogenic substrates, lanthanide complexes, gels and nanoparticles. The applications of these substrates for the detection of various glycosidases and the scope and limitations for each approach are discussed.en
dc.description.sponsorshipThe authors would like to acknowledge the Irish Research Council (IRC) Embark Initiative, IRCSET for postgraduate studentships (to HMB) and Science Foundation Ireland (SFI) for Principle Investigation Award (SFI PI 2013).en
dc.format.extent10576en
dc.format.extent10588en
dc.relation.ispartofseriesChemical Communicationsen
dc.relation.ispartofseries51en
dc.relation.ispartofseries53en
dc.rightsYen
dc.subjectsynthetic glycoconjugatesen
dc.subject.lcshsynthetic glycoconjugatesen
dc.titleRecent advances in the development of synthetic chemical probes for glycosidase enzymesen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/scanlaeen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/gunnlauten
dc.identifier.rssinternalid104794en
dc.identifier.doihttp://dx.doi.org/10.1039/c5cc02793den
dc.rights.ecaccessrightsopenAccess
dc.identifier.rssurihttp://www.scopus.com/inward/record.url?eid=2-s2.0-84934958385&partnerID=40&md5=821867edd395e8566e38d874df9c7c00en


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