dc.contributor.author | O'FARRELLY, CLIONA | en |
dc.contributor.author | FARES, MARIO | en |
dc.contributor.author | LLOYD, ANDREW | en |
dc.date.accessioned | 2015-12-09T11:43:46Z | |
dc.date.available | 2015-12-09T11:43:46Z | |
dc.date.issued | 2004 | en |
dc.date.submitted | 2004 | en |
dc.identifier.citation | Lynn, DJ, Lloyd, AT, Fares, MA, O'Farrelly, C, Evidence of positively selected sites in mammalian alpha-defensins., Molecular biology and evolution, 21, 5, 2004, 819-827 | en |
dc.identifier.other | Y | en |
dc.identifier.uri | http://hdl.handle.net/2262/75162 | |
dc.description | PUBLISHED | en |
dc.description.abstract | Alpha-defensins are a family of mammalian antimicrobial peptides that exhibit variable activity against a panel of microbes, including bacteria, fungi, and enveloped viruses. We have employed a maximum-likelihood approach to detect evidence of positive selection (adaptive evolution) in the evolution of these important molecules of the innate immune response. We have identified 14 amino acid sites that are predicted to be subject to positive selection. Furthermore, we show that all these sites are located in the mature antimicrobial peptide and not in the prepropeptide region of the molecule, implying that they are of functional importance. These results suggest that mammalian alpha-defensins have been under selective pressure to evolve in response to potentially infectious challenges by fast-evolving microbes. | en |
dc.description.sponsorship | We would like to thank two anonymous reviewers for helpful comments. This research was supported by the Food Institutional Research Measure (F.I.R.M.) Grant 01/R&D/D/135 from the Irish Department of Agriculture, Food and Rural Development. | en |
dc.format.extent | 819-827 | en |
dc.relation.ispartofseries | Molecular biology and evolution | en |
dc.relation.ispartofseries | 21 | en |
dc.relation.ispartofseries | 5 | en |
dc.rights | Y | en |
dc.subject | mammalian antimicrobial peptides | en |
dc.subject.lcsh | mammalian antimicrobial peptides | en |
dc.title | Evidence of positively selected sites in mammalian alpha-defensins. | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/ofarrecl | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/faresm | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/atlloyd | en |
dc.identifier.rssinternalid | 54061 | en |
dc.identifier.doi | http://dx.doi.org/10.1093/molbev/msh084 | en |
dc.rights.ecaccessrights | openAccess | |
dc.subject.TCDTheme | Immunology, Inflammation & Infection | en |
dc.identifier.rssuri | http://mbe.oxfordjournals.org/cgi/reprint/21/5/819 | en |