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dc.contributor.authorMOLLOY, ANNEen
dc.date.accessioned2015-12-09T11:33:11Z
dc.date.available2015-12-09T11:33:11Z
dc.date.issued2011en
dc.date.submitted2011en
dc.identifier.citationMills JL, Carter TC, Scott JM, Troendle JF, Gibney ER, Shane B, Kirke PN, Ueland PM, Brody LC, Molloy AM., Do high blood folate concentrations exacerbate metabolic abnormalities in people with low vitamin B-12 status?, American Journal of Clinical Nutrition, 94, 2, 2011, 495 - 500en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/75135
dc.descriptionPUBLISHEDen
dc.description.abstractABSTRACT Background: In elderly individuals with low serum vitamin B-12, those who have high serum folate have been reported to have greater abnormalities in the following biomarkers for vitamin B-12 defi- ciency: low hemoglobin and elevated total homocysteine (tHcy) and methylmalonic acid (MMA). This suggests that folate exacerbates vitamin B-12–related metabolic abnormalities. Objective: We determined whether high serum folate in individuals with low serum vitamin B-12 increases the deleterious effects of low vitamin B-12 on biomarkers of vitamin B-12 cellular function. Design: In this cross-sectional study, 2 507 university students provided data on medical history and exposure to folic acid and vitamin B-12 supplements. Blood was collected to measure serum and red blood cell folate (RCF), hemoglobin, plasma tHcy, and MMA, holotranscoba- lamin, and ferritin in serum. Results: In subjects with low vitamin B-12 concentrations ( , 148 pmol/L), those who had high folate concentrations ( . 30 nmol/L; group 1) did not show greater abnormalities in vitamin B-12 cellular function in any area than did those with lower folate concentrations ( 30 nmol/L; group 2). Group 1 had significantly higher holotrans- cobalamin and RCF, significantly lower tHcy, and nonsignificantly lower ( P = 0.057) MMA concentrations than did group 2. The groups did not differ significantly in hemoglobin or ferritin. Compared with group 2, group 1 had significantly higher mean intakes of folic acid and vitamin B-12 from supplements and fortified food. Conclusions: In this young adult population, high folate concen- trations did not exacerbate the biochemical abnormalities related to vitamin B-12 deficiency. These results provide reassurance that folic acid in fortified foods and supplements does not interfere with vitamin B-12 metabolism at the cellular level in a healthy population.en
dc.description.sponsorshipupported by the Intramural Research Program of the National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Developmenten
dc.format.extent495en
dc.format.extent500en
dc.relation.ispartofseriesAmerican Journal of Clinical Nutritionen
dc.relation.ispartofseries94en
dc.relation.ispartofseries2en
dc.rightsYen
dc.subjectlow serum vitamin B-12,en
dc.subject.lcshlow serum vitamin B-12,en
dc.titleDo high blood folate concentrations exacerbate metabolic abnormalities in people with low vitamin B-12 status?en
dc.typeJournal Articleen
dc.contributor.sponsorHealth Research Board (HRB)en
dc.contributor.sponsorNational Institutes of Health (NIH)en
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/amolloyen
dc.identifier.rssinternalid79000en
dc.rights.ecaccessrightsopenAccess
dc.subject.TCDThemeInternational Developmenten


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