Show simple item record

dc.contributor.authorSENGE, MATHIASen
dc.contributor.authorSCANLAN, EOINen
dc.date.accessioned2015-08-26T11:06:45Z
dc.date.available2015-08-26T11:06:45Z
dc.date.created2015en
dc.date.issued2015en
dc.date.submitted2015en
dc.identifier.citationMoylan C, Scanlan E.M, Senge M.O, Chemical synthesis and medicinal applications of glycoporphyrins, Current Medicinal Chemistry, 22, 19, 2015, 2238 - 2348en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/74512
dc.descriptionPUBLISHEDen
dc.descriptionExport Date: 22 August 2015en
dc.description.abstractThis review presents an in-depth overview of the modification of porphyrins with bioconjugates and their applications in medicine today. Porphyrin bioconjugates ranging from nucleotides to steroids are under active scrutiny. However, carbohydrates have been at the forefront of such research in recent years and offer significant potential. This is attributed to their own selectivity to lectins on the surface of cancer cells and their influence on the amphiphilicity of the porphyrin macrocycle. These characteristics and the tendency of porphyrin photosensitizers to accumulate in tumor tissues make glycoporphyrins promising candidates for use as photosensitizers. Thus, a detailed overview of the synthesis and biological evaluation of glycoporphyrins is given with a particular focus on their applications in photodynamic therapy and their future prospects as drug candidates have been reported.en
dc.description.sponsorshipOur work was supported by grants from Science Foundation Ireland (SFI P.I. 09/IN.1/B2650, 12/TIDA/B2381, and IvP 13/IA/1894) and the School of Chemistry (TCD).en
dc.format.extent2238en
dc.format.extent2348en
dc.relation.ispartofseriesCurrent Medicinal Chemistryen
dc.relation.ispartofseries22en
dc.relation.ispartofseries19en
dc.rightsYen
dc.subjectmodification of porphyrinsen
dc.subject.lcshmodification of porphyrinsen
dc.titleChemical synthesis and medicinal applications of glycoporphyrinsen
dc.typeJournal Articleen
dc.contributor.sponsorScience Foundation Ireland (SFI)en
dc.contributor.sponsorScience Foundation Ireland (SFI)en
dc.contributor.sponsorScience Foundation Ireland (SFI)en
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/sengemen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/scanlaeen
dc.identifier.rssinternalid105601en
dc.rights.ecaccessrightsopenAccess
dc.contributor.sponsorGrantNumberP.I. 09/IN.1/B2650en
dc.contributor.sponsorGrantNumberIvP 13/IA/1894en
dc.contributor.sponsorGrantNumber12/TIDA/B2381en
dc.identifier.rssurihttp://www.scopus.com/inward/record.url?eid=2-s2.0-84937045304&partnerID=40&md5=d6fb1b862ca4a33d4a91f43c9d579fd7en


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record