Browsing School of Pharmacy and Pharmaceutical Sciences by Date of Publication
Now showing items 1-20 of 630
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A study of pharmacy practice. Non-prescribed medicines sales and counselling 3
(Swedish Pharmaceutical Press, 1991) -
Mechanistic aspects of the degradation and drug release properties of poly-alpha-hydroxyl aliphatic ester nano- and microparticle
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2000)Particulate systems based on the polymers of lactic and glycolic acids have been extensively investigated as drug delivery technologies, particularly as vehicles to achieve controlled release. The release kinetics from ... -
Intestinal degradation and absorption kinetics of salmon calcitonin
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2000)The aim of this work was to investigate the intestinal degradation and absorption of a hydrophilic peptide, salmon calcitonin (sCT), and to evaluate the use of bile salt simple and mixed micellar systems as potential ... -
Factors affecting paclitaxel content in yew
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2000)The anti-cancer agent paclitaxel has been the subject of intense scientific evaluation since it was first isolated from the bark of the Pacific yew [T. brevifolia] in 1971. It is currently used extensively in the treatment ... -
Synthesis of intermediates for carbapenem antibiotics and synthetic analogues of dehydroepiandrosterone (DHEA)
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2000)The work presented in this thesis is divided into two parts. Part one consists of the synthesis and chemical modification of β-lactams as potential intermediates for carbapenem antibiotics. Part two describes the synthesis ... -
An investigation on the therapeutic properties of novel compounds in models of asthma, inflammation and delayed type hypersensitivity
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2000)There are many drugs on the market for the treatment of asthma, inflammation and delayed type hypersensitivity (DTH), however few are disease modifying. The potential therapeutic effect of three novel compounds, 3C8, 6C6 ... -
The design, synthesis and biochemical evaluation of novel flexible and conformationally restrained antiestrogens
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2000)This thesis is presented in four different sections. In the first section the synthesis of a number of structural (novel flexible) analogues of the antiestrogen drug tamoxifen is described. Preparation of novel conformationally ... -
A study of the release of the amphoteric drug amoxycillin from biodegradable polymers
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2000)Poly-alpha-hydroxy-aliphatic esters constitute a group of biodegradable polymers which have been actively investigated over the past three decades for the sustained release of drug compounds. A literature review revealed ... -
Novel pharmaceutical excipients
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2000)The research work performed in compiling this thesis can be divided into two broad areas, namely (a) the development, characterisation and examination of potential pharmaceutical applications of new de-aggregated grades ...
