Show simple item record

dc.contributor.authorBRACKEN, ADRIANen
dc.date.accessioned2015-05-06T14:30:06Z
dc.date.available2015-05-06T14:30:06Z
dc.date.issued2009en
dc.date.submitted2009en
dc.identifier.citationBrien GL, Bracken AP., Transcriptomics: Unravelling the biology of transcription factors and chromatin remodelers during development and differentiation, Seminars in Cell and Developmental Biology, 20, 7, 2009, 835 - 841en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/73861
dc.descriptionPUBLISHEDen
dc.description.abstractThe Polycomb group (PcG) proteins are transcriptional repressors that regulate lineage choices during development and differentiation. Recent studies have advanced our understanding of how the PcG proteins regulate cell fate decisions and how their deregulation potentially contributes to cancer. In this Review we discuss the emerging roles of long non-coding RNAs (ncRNAs) and a subset of transcription factors, which we call cell fate transcription factors, in the regulation of PcG association with target genes. We also speculate about how their deregulation contributes to tumorigenesis.en
dc.format.extent835en
dc.format.extent841en
dc.language.isoenen
dc.relation.ispartofseriesSeminars in Cell and Developmental Biologyen
dc.relation.ispartofseries20en
dc.relation.ispartofseries7en
dc.rightsYen
dc.subjectBONE-MARROW-CELLSen
dc.subjectHUMAN BREAST-TUMORSen
dc.subjectLONG NONCODING RNASen
dc.subjectGENOME-WIDE ANALYSISen
dc.subjectHEMATOPOIETIC STEM-CELLSen
dc.subjectACUTE PROMYELOCYTIC LEUKEMIAen
dc.subjectTRANSCRIPTION FACTOR-BINDINGen
dc.subjectCELL SELF-RENEWALen
dc.subjectTUMOR-SUPPRESSOR GENEen
dc.subjectACUTE MYELOID-LEUKEMIAen
dc.titleTranscriptomics: Unravelling the biology of transcription factors and chromatin remodelers during development and differentiationen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/brackeaen
dc.identifier.rssinternalid62025en
dc.identifier.doihttp://dx.doi.org/10.1016/j.semcdb.2009.07.010en
dc.rights.ecaccessrightsOpenAccess
dc.subject.TCDThemeCanceren
dc.subject.TCDThemeGenes & Societyen
dc.identifier.rssurihttp://www.ncbi.nlm.nih.gov/pubmed/19682593?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2
dc.identifier.orcid_id0000-0002-1547-9443en


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record