| dc.contributor.author | SCANLAN, EOIN | en |
| dc.contributor.author | SENGE, MATHIAS | en |
| dc.date.accessioned | 2015-05-06T14:27:15Z | |
| dc.date.available | 2015-05-06T14:27:15Z | |
| dc.date.issued | 2012 | en |
| dc.date.submitted | 2012 | en |
| dc.identifier.citation | Daly R, Vaz G, Davies AM, Senge MO, Scanlan EM, Synthesis and biological evaluation of a library of glycoporphyrin compounds., Chemistry (Weinheim an der Bergstrasse, Germany), 18, 46, 2012, 14671-9 | en |
| dc.identifier.other | Y | en |
| dc.identifier.uri | http://hdl.handle.net/2262/73859 | |
| dc.description | PUBLISHED | en |
| dc.description | PubMed ID: 23018896 | en |
| dc.description.abstract | A library of glycosylated
porphyrins (Glycoporphyrins) was
prepared and evaluated for their PDT
activity against oesophageal squamous
cell carcinoma cell line OE21 in vitro.
Synthetic methodology was developed
to allow incorporation of biologically
active carbohydrates including the histo
blood group antigen trisaccharide,
Lewis x onto the porphyrin backbone.
The effect of the carbohydrate group
and substitution pattern on the PDT
activity, cell uptake and subcellular
localisation of the glycoporphyrin
compounds is reported. | en |
| dc.description.sponsorship | This work was supported by grants from the School of Chemistry (TCD), the Health
Research Board (translational research award 2007 TRA/2007/11), Science Foundation
Ireland (SFI P.I. 09/IN.1/B2650) Fundac?o da Ciencia e Tecnologia (SFRH / BD /
62364 / 2009) and IRCSET. | en |
| dc.format.extent | 14671-9 | en |
| dc.language.iso | en | en |
| dc.relation.ispartofseries | Chemistry (Weinheim an der Bergstrasse, Germany) | en |
| dc.relation.ispartofseries | 18 | en |
| dc.relation.ispartofseries | 46 | en |
| dc.rights | Y | en |
| dc.title | Synthesis and biological evaluation of a library of glycoporphyrin compounds. | en |
| dc.type | Journal Article | en |
| dc.type.supercollection | scholarly_publications | en |
| dc.type.supercollection | refereed_publications | en |
| dc.identifier.peoplefinderurl | http://people.tcd.ie/scanlae | en |
| dc.identifier.peoplefinderurl | http://people.tcd.ie/sengem | en |
| dc.identifier.rssinternalid | 83167 | en |
| dc.identifier.doi | http://dx.doi.org/10.1002/chem.201202064 | en |
| dc.rights.ecaccessrights | OpenAccess | |
| dc.subject.TCDTheme | Cancer | en |
