Show simple item record

dc.contributor.authorSENGE, MATHIASen
dc.contributor.authorRYAN, AOIFEen
dc.date.accessioned2015-05-06T10:28:28Z
dc.date.available2015-05-06T10:28:28Z
dc.date.issued2014en
dc.date.submitted2014en
dc.identifier.citationRyan, A. A.; Ebrahim, M. M.; Petitdemange, R.; Vaz, G. M.; Paszko, E.; Sergeeva, N. N.; Senge, M. O., Lead structures for applications in photodynamic therapy. 5. Synthesis and biological evaluation of water soluble phosphorus (V) 5,10,15,20-tetraalkylporphyrins for PDT., Photodiagnosis and Photodynamic Therapy, 11, 2014, 510 515en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/73847
dc.descriptionPUBLISHEDen
dc.description.abstractSummary Improved photosensitizers for use in photomedicine must possess good water-solubility and optimal photophysical properties. Phosphorus(V) porphyrins fulfill these criteria and are a class of porphyrins with significant potential applications in phototherapy. Five phosphorus(V) porphyrins bearing alkyl substituents have been synthesized. Reasonable to good yields were obtained for all P(V) insertions and all compounds underwent biological evaluation for their PDT activity on two esophageal cancer cell lines, OE33 and SKGT-4. Their cellular uptake was investigated using a high content screening method. Notably, three compounds displayed good uptake and using the MTS cell proliferation assay, two were shown to have photocytotoxicity comparable to mTHPC (Temoporfin®) with IC50 values of 6.5 and 5.5 μM.en
dc.description.sponsorshipThis work was supported by grants from Science Foundation Ireland (SFI P.I. 09/IN.1/B2650 and 12/TIDA/B2381) and the Irish Research Councilen
dc.format.extent510 515en
dc.language.isoenen
dc.relation.ispartofseriesPhotodiagnosis and Photodynamic Therapyen
dc.relation.ispartofseries11en
dc.rightsYen
dc.subjectPhotodynamic therapy; Photosensitizers; Phosphorous; Porphyrins; Cancer; Esophageal canceren
dc.subject.lcshPhotodynamic therapy; Photosensitizers; Phosphorous; Porphyrins; Cancer; Esophageal canceren
dc.titleLead structures for applications in photodynamic therapy. 5. Synthesis and biological evaluation of water soluble phosphorus (V) 5,10,15,20-tetraalkylporphyrins for PDT.en
dc.typeJournal Articleen
dc.contributor.sponsorScience Foundation Ireland (SFI)en
dc.contributor.sponsorScience Foundation Ireland (SFI)en
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/sengemen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/ryana41en
dc.identifier.rssinternalid99899en
dc.identifier.doihttp://dx.doi.org/10.1016/j.pdpdt.2014.07.003en
dc.rights.ecaccessrightsopenAccess
dc.contributor.sponsorGrantNumber12/TIDA/B2381en
dc.contributor.sponsorGrantNumber09/IN.1/B2650en


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record