dc.contributor.author | SENGE, MATHIAS | en |
dc.contributor.author | RYAN, AOIFE | en |
dc.date.accessioned | 2015-05-06T10:28:28Z | |
dc.date.available | 2015-05-06T10:28:28Z | |
dc.date.issued | 2014 | en |
dc.date.submitted | 2014 | en |
dc.identifier.citation | Ryan, A. A.; Ebrahim, M. M.; Petitdemange, R.; Vaz, G. M.; Paszko, E.; Sergeeva, N. N.; Senge, M. O., Lead structures for applications in photodynamic therapy. 5. Synthesis and biological evaluation of water soluble phosphorus (V) 5,10,15,20-tetraalkylporphyrins for PDT., Photodiagnosis and Photodynamic Therapy, 11, 2014, 510 515 | en |
dc.identifier.other | Y | en |
dc.identifier.uri | http://hdl.handle.net/2262/73847 | |
dc.description | PUBLISHED | en |
dc.description.abstract | Summary
Improved photosensitizers for use in photomedicine must possess good water-solubility
and optimal photophysical properties. Phosphorus(V) porphyrins fulfill these criteria and
are a class of porphyrins with significant potential applications in phototherapy. Five
phosphorus(V) porphyrins bearing alkyl substituents have been synthesized.
Reasonable to good yields were obtained for all P(V) insertions and all compounds
underwent biological evaluation for their PDT activity on two esophageal cancer cell
lines, OE33 and SKGT-4. Their cellular uptake was investigated using a high content
screening method. Notably, three compounds displayed good uptake and using the
MTS cell proliferation assay, two were shown to have photocytotoxicity comparable to
mTHPC (Temoporfin®) with IC50 values of 6.5 and 5.5 μM. | en |
dc.description.sponsorship | This work was supported by grants from Science Foundation Ireland (SFI P.I.
09/IN.1/B2650 and 12/TIDA/B2381) and the Irish Research Council | en |
dc.format.extent | 510 515 | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | Photodiagnosis and Photodynamic Therapy | en |
dc.relation.ispartofseries | 11 | en |
dc.rights | Y | en |
dc.subject | Photodynamic therapy; Photosensitizers; Phosphorous; Porphyrins; Cancer; Esophageal cancer | en |
dc.subject.lcsh | Photodynamic therapy; Photosensitizers; Phosphorous; Porphyrins; Cancer; Esophageal cancer | en |
dc.title | Lead structures for applications in photodynamic therapy. 5. Synthesis and biological evaluation of water soluble phosphorus (V) 5,10,15,20-tetraalkylporphyrins for PDT. | en |
dc.type | Journal Article | en |
dc.contributor.sponsor | Science Foundation Ireland (SFI) | en |
dc.contributor.sponsor | Science Foundation Ireland (SFI) | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/sengem | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/ryana41 | en |
dc.identifier.rssinternalid | 99899 | en |
dc.identifier.doi | http://dx.doi.org/10.1016/j.pdpdt.2014.07.003 | en |
dc.rights.ecaccessrights | openAccess | |
dc.contributor.sponsorGrantNumber | 12/TIDA/B2381 | en |
dc.contributor.sponsorGrantNumber | 09/IN.1/B2650 | en |