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dc.contributor.authorSENGE, MATHIASen
dc.date.accessioned2015-05-05T15:36:15Z
dc.date.available2015-05-05T15:36:15Z
dc.date.issued2014en
dc.date.submitted2014en
dc.identifier.citationRogers, L.; Senge, M. O., The translocator protein as a potential molecular target for improved treatment efficacy in photodynamic therapy., Future Medicinal Chemistry, 6, 2014, 775 792en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/73824
dc.descriptionPUBLISHEDen
dc.description.abstractAbstract: Since it’s serendipitous discovery by researchers over thirty years ago, the translocator protein (18 kDa) (TSPO) has been demonstrated to play an important role in a multitude of critical biological processes. Although implemented as a novel therapeutic and diagnostic tool for a variety of disease states, its most promising role is as a molecular target for anti-cancer treatments such as photodynamic therapy (PDT). This review gives an overview of the attempts made by researchers to design porphyrin based photosensitizers for use as anti-cancer therapeutics in PDT as well as improved imaging agents for diagnostic purposes. With a better understanding of the structure and function of the TSPO, the synthesis of porphyrins for use in PDT with optimum binding affinities will become ever more possible.en
dc.description.sponsorshipOur work was supported by grants from Science Foundation Ireland (SFI P.I. 09/IN.1/B2650 and 12/TIDA/B2381).en
dc.format.extent775 792en
dc.language.isoenen
dc.relation.ispartofseriesFuture Medicinal Chemistryen
dc.relation.ispartofseries6en
dc.rightsYen
dc.subjecttranslocator protein (18 kDa) (TSPO)en
dc.subject.lcshtranslocator protein (18 kDa) (TSPO)en
dc.titleThe translocator protein as a potential molecular target for improved treatment efficacy in photodynamic therapy.en
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/sengemen
dc.identifier.rssinternalid99840en
dc.rights.ecaccessrightsopenAccess


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