The translocator protein as a potential molecular target for improved treatment efficacy in photodynamic therapy.
Citation:
Rogers, L.; Senge, M. O., The translocator protein as a potential molecular target for improved treatment efficacy in photodynamic therapy., Future Medicinal Chemistry, 6, 2014, 775 792Download Item:

Abstract:
Abstract: Since it’s serendipitous discovery by researchers over thirty years ago,
the translocator protein (18 kDa) (TSPO) has been demonstrated to play an
important role in a multitude of critical biological processes. Although implemented
as a novel therapeutic and diagnostic tool for a variety of disease states, its most
promising role is as a molecular target for anti-cancer treatments such as
photodynamic therapy (PDT). This review gives an overview of the attempts made
by researchers to design porphyrin based photosensitizers for use as anti-cancer
therapeutics in PDT as well as improved imaging agents for diagnostic purposes.
With a better understanding of the structure and function of the TSPO, the synthesis
of porphyrins for use in PDT with optimum binding affinities will become ever more
possible.
Author's Homepage:
http://people.tcd.ie/sengemDescription:
PUBLISHED
Author: SENGE, MATHIAS
Type of material:
Journal ArticleCollections:
Series/Report no:
Future Medicinal Chemistry6
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Full text availableKeywords:
translocator protein (18 kDa) (TSPO)Licences: