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dc.contributor.authorBOKDE, ARUNen
dc.date.accessioned2015-03-11T13:04:38Z
dc.date.available2015-03-11T13:04:38Z
dc.date.issued2014en
dc.date.submitted2014en
dc.identifier.citationKhan W, Giampietro V, Ginestet C, Dell'Acqua F, Bouls D, Newhouse S, Dobson R, Banaschewski T, Barker GJ, Bokde AL, Büchel C, Conrod P, Flor H, Frouin V, Garavan H, Gowland P, Heinz A, Ittermann B, Lemaître H, Nees F, Paus T, Pausova Z, Rietschel M, Smolka MN, Ströhle A, Gallinat J, Westman E, Schumann G, Lovestone S, Simmons A; IMAGEN consortium, No differences in hippocampal volume between carriers and non-carriers of the ApoE ε4 and ε2 alleles in young healthy adolescents, Journal of Alzheimer's Disease, 40, 1, 2014, 37-43en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/73558
dc.descriptionACCEPTEDen
dc.description.abstractIndividuals with alcohol-dependent parents show an elevated risk of developing alcohol-related problems themselves. Modulations of the mesolimbic reward circuit have been postulated as a pre-existing marker of alcoholism. We tested whether a positive family history of alcoholism is correlated with ventral striatum functionality during a reward task. All participants performed a modified version of the monetary incentive delay task while their brain responses were measured with functional magnetic resonance imaging. We compared 206 healthy adolescents (aged 13-15) who had any first- or second-degree relative with alcoholism to 206 matched controls with no biological relative with alcoholism. Reward anticipation as well as feedback of win recruited the ventral striatum in all participants, but adolescents with a positive family history of alcoholism did not differ from their matched peers. Also we did not find any correlation between family history density and reward anticipation or feedback of win. This finding of no differences did not change when we analyzed a subsample of 77 adolescents with at least one parent with alcohol use disorder and their matched controls. Because this result is in line with another study reporting no differences between children with alcohol-dependent parents and controls at young age, but contrasts with studies of older individuals, one might conclude that at younger age the effect of family history has not yet exerted its influence on the still developing mesolimbic reward circuit.en
dc.description.sponsorshipSupport for this study was provided by the IMA- GEN project, which receives research funding from the European Community’s Sixth Framework Program (LSHM-CT-2007-037286) and coordinated project ADAMS (242257), as well as the NIHR Biomedical Research Centre for Mental Health and NIHR Biomed- ical Research Unit for Dementia at South London and Maudsley NHS Foundation Trust and Institute of Psy- chiatry, King’s College London, Alzheimer Research UK and the IMI funded European Medical Information Framework. GJB received honoraria for teaching dur- ing the course of this study and receives consultancy payments from IXICO.en
dc.format.extent37-43en
dc.language.isoenen
dc.relation.ispartofseriesJournal of Alzheimer's Diseaseen
dc.relation.ispartofseries40en
dc.relation.ispartofseries1en
dc.rightsYen
dc.subjectalcohol-dependent parenten
dc.subject.lcshalcohol-dependent parenten
dc.titleNo differences in hippocampal volume between carriers and non-carriers of the ApoE ε4 and ε2 alleles in young healthy adolescentsen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/bokdeaen
dc.identifier.rssinternalid100094en
dc.identifier.doihttp://dx.doi.org/10.3233/JAD-131841en
dc.rights.ecaccessrightsopenAccess
dc.subject.TCDThemeAgeingen
dc.subject.TCDThemeNeuroscienceen
dc.subject.TCDTagADOLESCENTen
dc.subject.TCDTagAge related diseasesen
dc.subject.TCDTagHuman geneticsen
dc.subject.TCDTagImaging Techniquesen


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