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dc.contributor.authorGILL, MICHAELen
dc.date.accessioned2015-03-11T12:28:21Z
dc.date.available2015-03-11T12:28:21Z
dc.date.issued2014en
dc.date.submitted2014en
dc.identifier.citationMartin J, Cooper M, Hamshere ML, Pocklington A, Scherer SW, Kent L, Gill M, Owen MJ, Williams N, O'Donovan MC, Thapar A, Holmans P, Biological overlap of attention-deficit/hyperactivity disorder and autism spectrum disorder: evidence from copy number variants., Journal of the American Academy of Child and Adolescent Psychiatry, 53, 7, 2014, 761-70.e26en
dc.identifier.issn0890-8567en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/73539
dc.descriptionPUBLISHEDen
dc.description.abstractObjective Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) often co-occur and share genetic risks. The aim of this analysis was to determine more broadly whether ADHD and ASD share biological underpinnings. Method We compared copy number variant (CNV) data from 727 children with ADHD and 5,081 population controls to data from 996 individuals with ASD and an independent set of 1,287 controls. Using pathway analyses, we investigated whether CNVs observed in individuals with ADHD have an impact on genes in the same biological pathways as on those observed in individuals with ASD. Results The results suggest that the biological pathways affected by CNVs in ADHD overlap with those affected by CNVs in ASD more than would be expected by chance. Moreover, this was true even when specific CNV regions common to both disorders were excluded from the analysis. After correction for multiple testing, genes involved in 3 biological processes (nicotinic acetylcholine receptor signalling pathway, cell division, and response to drug) showed significant enrichment for case CNV hits in the combined ADHD and ASD sample. Conclusion The results of this study indicate the presence of significant overlap of shared biological processes disrupted by large rare CNVs in children with these 2 neurodevelopmental conditions.en
dc.description.sponsorshipThis work has been supported by the Medical Research Council (UK), Baily Thomas Charitable Trust, the Wellcome Trust and Action Research, the University of Toronto McLaughlin Centre, the Canadian Institutes of Health Research, and Genome Canada.en
dc.format.extent761-70.e26en
dc.language.isoenen
dc.relation.ispartofseriesJournal of the American Academy of Child and Adolescent Psychiatryen
dc.relation.ispartofseries53en
dc.relation.ispartofseries7en
dc.rightsYen
dc.subjectADHD, ASD, pathway analysis, CNVs, comorbidityen
dc.subject.lcshADHD, ASD, pathway analysis, CNVs, comorbidityen
dc.titleBiological overlap of attention-deficit/hyperactivity disorder and autism spectrum disorder: evidence from copy number variants.en
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/mgillen
dc.identifier.rssinternalid101825en
dc.identifier.doihttp://dx.doi.org/10.1016/j.jaac.2014.03.004en
dc.rights.ecaccessrightsopenAccess
dc.identifier.orcid_id0000-0003-0206-5337en


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