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dc.contributor.authorO'MARA, SHANEen
dc.contributor.authorO'MARA, SHANE MICHAELen
dc.date.accessioned2015-03-04T14:02:48Z
dc.date.available2015-03-04T14:02:48Z
dc.date.issued2015en
dc.date.submitted2015en
dc.identifier.citationTsanov, M. O'Mara, S.M., Decoding signal processing in thalamo-hippocampal circuitry: Implications for theories of memory and spatial processing, Brain Research, 1621, 2015, 368 379en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/73409
dc.descriptionPUBLISHEDen
dc.description.abstractA major tool in understanding how information is processed in the brain is the analysis of neuronal output at each hierarchical level through which neurophysiological signals are propagated. Since the experimental brain operation performed on Henry Gustav Molaison (known as patient H.M.) in 1953, the hippocampal formation has gained special attention, resulting in a very large number of studies investigating signals processed by the hippocampal formation. One of the main information streams to the hippocampal formation, vital for episodic memory formation, arises from thalamo-hippocampal projections, as there is extensive connectivity between these structures. This connectivity is sometimes overlooked by theories of memory formation by the brain, in favour of theories with a strong cortico-hippocampal flavour. In this review, we attempt to address some of the complexity of the signals processed within the thalamo-hippocampal circuitry. To understand the signals encoded by the anterior thalamic nuclei in particular, we review key findings from electrophysiological, anatomical, behavioural and computational studies. We include recent findings elucidating the integration of different signal modalities by single thalamic neurons; we focus in particular on the propagation of two prominent signals: head directionality and theta rhythm. We conclude that thalamo-hippocampal processing provides a centrally important, substantive, and dynamic input modulating and moderating hippocampal spatial and mnemonic processingen
dc.description.sponsorshipThis work was supported by Science Foundation Ireland, the Health Research Board and the Wellcome Trust Biomedical Research Partnership grants to Marian Tsanov and Shane O׳Mara.en
dc.format.extent368 379en
dc.language.isoenen
dc.relation.ispartofseriesBrain Researchen
dc.relation.ispartofseries1621en
dc.rightsYen
dc.subjectHippocampus; Anterior thalamus; Head direction cells; Theta rhythm; Place cellsen
dc.subject.lcshHippocampus; Anterior thalamus; Head direction cells; Theta rhythm; Place cellsen
dc.titleDecoding signal processing in thalamo-hippocampal circuitry: Implications for theories of memory and spatial processingen
dc.typeJournal Articleen
dc.contributor.sponsorScience Foundation Ireland (SFI)en
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/smomaraen
dc.identifier.rssinternalid101519en
dc.identifier.doihttp://dx.doi.org/10.1016/j.brainres.2014.12.003en
dc.rights.ecaccessrightsopenAccess
dc.identifier.rssurihttp://www.scopus.com/inward/record.url?eid=2-s2.0-84920455493&partnerID=40&md5=75ee4350979c68071f47fe6f4675b36aen


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