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dc.contributor.authorWALSH, PATRICKen
dc.date.accessioned2015-02-16T16:59:56Z
dc.date.available2015-02-16T16:59:56Z
dc.date.issued2012en
dc.date.submitted2012en
dc.identifier.citationRussell, SE and Walsh, PT, Sterile inflammation - do innate lymphoid cell subsets play a role?, Frontiers in Immunology, 3, 2012, 246-en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/73254
dc.descriptionPUBLISHEDen
dc.description.abstractThe recent identification of several novel innate lymphoid cell (iLC) subsets has increased our understanding of the mechanisms which link the innate and adaptive immune systems. While the contribution of these subsets toward the pathogenesis of human disease remains largely to be determined, it seems likely that they will play a particularly important role in sterile inflammatory settings where the innate response is seen as a critical mediator of inflammation. Several recent studies have highlighted the role of endogenous damage-associated molecular patterns such as IL-33, IL-1α, and IL-1β in promoting lymphoid cell responses. This review discusses the influence of such endogenous danger signals on novel iLCs such as lymphoid tissue-inducer cells, innate type 2 helper cells, and γδ T cells and explores how these responses may contribute to the development of an inflammatory response in a sterile setting.en
dc.format.extent246en
dc.language.isoenen
dc.relation.ispartofseriesFrontiers in Immunologyen
dc.relation.ispartofseries3en
dc.rightsYen
dc.subjectγδ T cellen
dc.subjecttype 2 response;en
dc.subjecttype 1 responseen
dc.subjectsterile inflammationen
dc.subjectinnate lymphoid cellen
dc.titleSterile inflammation - do innate lymphoid cell subsets play a role?en
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/walshp10en
dc.identifier.rssinternalid80993en
dc.rights.ecaccessrightsopenAccess
dc.subject.TCDThemeImmunology, Inflammation & Infectionen


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