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dc.contributor.authorMORAN, GARYen
dc.contributor.authorSULLIVAN, DEREKen
dc.date.accessioned2015-02-13T14:58:57Z
dc.date.available2015-02-13T14:58:57Z
dc.date.issued2015en
dc.date.submitted2015en
dc.identifier.citationDerek J. Sullivan, Judith Berman, Lawrence C. Myers, Gary P. Moran, Telomeric ORFS in Candida albicans : Does Mediator Tail Wag the Yeast?, PLoS Pathogens, 11, 2, 2015, e1004614-en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/73193
dc.descriptionPUBLISHEDen
dc.description.abstractRecent studies of fungal genomes have shown that subtelomeric regions of chromosomes are areas of rapid evolution that facilitate adaptation to novel niches [1]. Several years ago, analysis of the genome of the human pathogenic yeast Candida albicans revealed the presence of a large family of telomeric orfs (TLO genes) [2]. The function of this gene family remained an enigma in C. albicans genetics for many years; however, recent studies have revealed that the TLO genes encode a subunit of the Mediator complex with roles in transcriptional regulation [3,4]. This gene family expansion is unique to C. albicans, the species responsible for the majority of human yeast infections and the species that is most commonly recovered as a human commensal. If selective pressures in the host have driven this expansion, it is likely that this gene family somehow contributes to the success of C. albicans as a commensal and opportunistic pathogen. To support this hypothesis, it was first necessary to determine the exact function of Tlo proteins in C. albicans. Armed with this knowledge, investigators are now beginning to understand how possession of multiple copies of TLO could contribute to the virulence properties of C. albicans.en
dc.format.extente1004614en
dc.language.isoenen
dc.relation.ispartofseriesPLoS Pathogensen
dc.relation.ispartofseries11en
dc.relation.ispartofseries2en
dc.rightsYen
dc.subjectCandida albicansen
dc.subjectGene regulationen
dc.subjectGene expressionen
dc.subjectDNA transcriptionen
dc.subjectTranscription factorsen
dc.subjectFungal structureen
dc.subjectSaccharomyces cerevisiaeen
dc.subjectYeasten
dc.titleTelomeric ORFS in Candida albicans : Does Mediator Tail Wag the Yeast?en
dc.typeJournal Articleen
dc.contributor.sponsorScience Foundation Ireland (SFI)en
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/djsullvnen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/gmoranen
dc.identifier.rssinternalid100718en
dc.identifier.doihttp://dx.doi.org/10.1371/journal.ppat.1004614en
dc.rights.ecaccessrightsopenAccess
dc.contributor.sponsorGrantNumberRFP.1/GEN/3042 and RFP.1/GEN/3044en
dc.subject.TCDThemeGenes & Societyen
dc.subject.TCDThemeImmunology, Inflammation & Infectionen
dc.subject.TCDTagMolecular Biologyen
dc.subject.TCDTagMycology and fungal pathogenesisen
dc.subject.TCDTagOral microbiologyen
dc.identifier.rssurihttp://www.plospathogens.org/article/fetchObject.action?uri=info:doi/10.1371/journal.ppat.1004614&representation=PDFen
dc.identifier.orcid_id0000-0003-0195-9697en


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