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dc.contributor.authorHOKAMP, KARSTENen
dc.contributor.authorKROGER, CARSTENen
dc.date.accessioned2015-02-02T15:45:50Z
dc.date.available2015-02-02T15:45:50Z
dc.date.issued2013en
dc.date.submitted2013en
dc.identifier.citationKr?ger C, Colgan A, Srikumar S, H?ndler K, Sivasankaran SK, Hammarl?f DL, Canals R, Grissom JE, Conway T, Hokamp K, Hinton JC, An infection-relevant transcriptomic compendium for Salmonella enterica Serovar Typhimurium., Cell host & microbe, 14, 6, 2013, 683-95en
dc.identifier.issn1931-3128en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/73152
dc.descriptionPUBLISHEDen
dc.description.abstractBacterial transcriptional networks consist of hundreds of transcription factors and thousands of promoters. However, the true complexity of transcription in a bacterial pathogen and the effect of the environments encountered during infection remain to be established. We present a simplified approach for global promoter identification in bacteria using RNA-seq-based transcriptomic analyses of 22 distinct infection-relevant environmental conditions. Individual RNA samples were combined to identify most of the 3,838 Salmonella enterica serovar Typhimurium promoters in just two RNA-seq runs. Individual in vitro conditions stimulated characteristic transcriptional signatures, and the suite of 22 conditions induced transcription of 86% of all S. Typhimurium genes. We highlight the environmental conditions that induce the Salmonella pathogenicity islands and present a small RNA expression landscape of 280 sRNAs. This publicly available compendium of environmentally controlled expression of every transcriptional feature of S. Typhimurium constitutes a useful resource for the bacterial research community.en
dc.format.extent683-95en
dc.language.isoenen
dc.relation.ispartofseriesCell host & microbeen
dc.relation.ispartofseries14en
dc.relation.ispartofseries6en
dc.rightsYen
dc.subjectGeneticsen
dc.titleAn infection-relevant transcriptomic compendium for Salmonella enterica Serovar Typhimurium.en
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/kahokampen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/krogercen
dc.identifier.rssinternalid98993en
dc.identifier.doihttp://dx.doi.org/10.1016/j.chom.2013.11.010en
dc.rights.ecaccessrightsopenAccess
dc.subject.TCDThemeGenes & Societyen


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