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dc.contributor.authorO'CONNELL, REDMONDen
dc.contributor.authorROBERTSON, IANen
dc.contributor.authorBOKDE, ARUNen
dc.contributor.authorNOLAN, HUGHen
dc.date.accessioned2015-01-09T16:43:18Z
dc.date.available2015-01-09T16:43:18Z
dc.date.issued2013en
dc.date.submitted2013en
dc.identifier.citationBalsters JH, O'Connell RG, Galli A, Nolan H, Greco E, Kilcullen SM, Bokde AL, Lai R, Upton N, Robertson IH, Changes in resting connectivity with age: A simultaneous electroencephalogram and functional magnetic resonance imaging investigation., Neurobiology of Aging, 34, 9, 2013, 2194 - 2207en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/72977
dc.descriptionPUBLISHEDen
dc.description.abstractResting fluctuations in the blood oxygenation level-dependent signal have attracted considerable interest for their sensitivity to pathological brain processes. However, these analyses are susceptible to confound by nonneural physiological factors such as vasculature, breathing, and head movement which is a concern when investigating elderly or pathological groups. Here, we used simultaneous electroencephalogram (EEG) and functional magnetic resonance imaging (fMRI) (EEG/fMRI) to constrain the analysis of resting state networks (RSNs) and identify aging differences. Four of 26 RSNs showed fMRI and EEG/fMRI group differences; anterior default-mode network, left frontal-parietal network, bilateral middle frontal, and postcentral gyri. Seven RSNs showed only EEG/fMRI differences suggesting the combination of these 2 methods might be more sensitive to age-related neural changes than fMRI alone. Five RSNs showed only fMRI differences and might reflect nonneural group differences. Activity within some EEG/fMRI RSNs was better explained by neuropsychological measures (Mini Mental State Examination and Stroop) than age. These results support previous studies suggesting that age-related changes in specific RSNs are neural in origin, and show that changes in some RSNs relate better to elderly cognition than age.en
dc.format.extent2194en
dc.format.extent2207en
dc.language.isoenen
dc.relation.ispartofseriesNeurobiology of Agingen
dc.relation.ispartofseries34en
dc.relation.ispartofseries9en
dc.rightsYen
dc.subjectPrefrontal cortexen
dc.subjectHippocampusen
dc.subjectDefault mode networken
dc.subjectResting-state networksen
dc.subjectSimultaneous EEG/fMRIen
dc.subjectagingen
dc.titleChanges in resting connectivity with age: A simultaneous electroencephalogram and functional magnetic resonance imaging investigation.en
dc.typeJournal Articleen
dc.contributor.sponsorScience Foundation Ireland (SFI)en
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/reoconneen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/irobertsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/nolanh4en
dc.identifier.peoplefinderurlhttp://people.tcd.ie/bokdeaen
dc.identifier.rssinternalid90764en
dc.identifier.doihttp://dx.doi.org/10.1016/j.neurobiolaging.2013.03.004en
dc.rights.ecaccessrightsopenAccess
dc.contributor.sponsorGrantNumberstokesen
dc.subject.TCDThemeAgeingen


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