Metabolism of inflammation limited by AMPK and pseudo-starvation.
Item Type:Journal Article
Citation:O'Neill LA, Hardie DG, Metabolism of inflammation limited by AMPK and pseudo-starvation., Nature, 493, 7432, 2013, 346-355
Metabolism of inflammation.pdf (Published (author's copy) - Peer Reviewed) 3.671Mb
Metabolic changes in cells that participate in inflammation, such as activated macrophages and T-helper 17 cells, include a shift towards enhanced glucose uptake, glycolysis and increased activity of the pentose phosphate pathway. Opposing roles in these changes for hypoxia-inducible factor 1α and AMP-activated protein kinase have been proposed. By contrast, anti-inflammatory cells, such as M2 macrophages, regulatory T cells and quiescent memory T cells, have lower glycolytic rates and higher levels of oxidative metabolism. Some anti-inflammatory agents might act by inducing, through activation of AMP-activated protein kinase, a state akin to pseudo-starvation. Altered metabolism may thus participate in the signal-directed programs that promote or inhibit inflammation.
Author: O'NEILL, LUKE
Type of material:Journal Article
Availability:Full text available
Subject (TCD):Immunology, Inflammation & Infection