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dc.contributor.authorTAJBER, LIDIAen
dc.contributor.authorHEALY, ANNEen
dc.date.accessioned2015-01-06T15:28:54Z
dc.date.available2015-01-06T15:28:54Z
dc.date.issued2015en
dc.date.submitted2015en
dc.identifier.citationAmaro MI, Tajber L, Corrigan OI, Healy AM, Co-spray dried carbohydrate microparticles: crystallisation delay/inhibition and improved aerosolization characteristics through the incorporation of hydroxypropyl-?-cyclodextrin with amorphous raffinose or trehalose, Pharmaceutical Research, 32, 1, 2015, 180 - 195en
dc.identifier.issn0724-8741en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/72932
dc.descriptionPUBLISHEDen
dc.description.abstractPURPOSE: To formulate and investigate the physicochemical properties, physical stability and aerosolization characteristics of nanoporous/nanoparticulate microparticles (NPMPs) prepared by co-spray drying the sugars raffinose pentahydrate (R) or trehalose dihydrate (T) with the cyclic oligosaccharide hydroxypropyl-β-cyclodextrin (HPβCD). METHODS: Production of powders was carried out using a laboratory scale spray dryer. The resulting powders were characterised by X-ray powder diffraction (XRPD), scanning electron microscopy (SEM), laser diffraction particle sizing, specific surface area analysis (SSA), Fourier transform infrared (FTIR), differential scanning calorimetry (DSC), dynamic vapour sorption (DVS) and aerodynamic assessment using a Next Generation Impactor (NGI). RESULTS: Powders were amorphous and composed of spherical, porous microparticles with reduced particle size and high specific surface area (~100 m2/g). DSC scans showed a single glass transition temperature. FTIR was indicative of the existence of molecular interactions between the carbohydrates. DVS analysis showed an increase in the critical relative humidity (RH) of raffinose and trehalose and eventual crystallization inhibition with increasing concentration of HPβCD. The in vitro deposition showed powders formulated with HPβCD had higher recovered emitted dose and fine particle fraction (<5 μm) than raffinose and trehalose spray dried alone. CONCLUSIONS: The co-spray drying of raffinose or trehalose with HPβCD results in powders with improved physicochemical characteristics, physical stability and aerodynamic behaviour compared to spray-dried raffinose/trehalose particles, constituting improved potential drug-carrier systems for pulmonary delivery.en
dc.format.extent180en
dc.format.extent195en
dc.language.isoenen
dc.relation.ispartofseriesPharmaceutical Researchen
dc.relation.ispartofseries32en
dc.relation.ispartofseries1en
dc.rightsYen
dc.subjectAerosolen
dc.titleCo-spray dried carbohydrate microparticles: crystallisation delay/inhibition and improved aerosolization characteristics through the incorporation of hydroxypropyl-?-cyclodextrin with amorphous raffinose or trehaloseen
dc.typeJournal Articleen
dc.contributor.sponsorScience Foundation Ireland (SFI)en
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/healyamen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/ltajberen
dc.identifier.rssinternalid98538en
dc.identifier.doi10.1007/s11095-014-1454-8en
dc.rights.ecaccessrightsopenAccess
dc.contributor.sponsorGrantNumber07/SRC/B1154; SFI/12/RC/2275en
dc.subject.TCDThemeNanoscience & Materialsen
dc.subject.TCDTagDrug development and evaluationen
dc.identifier.orcid_id0000-0001-5093-9786en


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