Show simple item record

dc.contributor.authorHEALY, ANNEen
dc.date.accessioned2015-01-06T14:35:36Z
dc.date.available2015-01-06T14:35:36Z
dc.date.issued2014en
dc.date.submitted2014en
dc.identifier.citationTewes F, Ehrhardt C, Healy AM, Superparamagnetic iron oxide nanoparticles (SPIONs)-loaded Trojan microparticles for targeted aerosol delivery to the lung, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V, 86, 1, 2014, 98-104en
dc.identifier.issn0939-6411en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/72926
dc.descriptionPUBLISHEDen
dc.description.abstractTargeted aerosol delivery to specific regions of the lung may improve therapeutic efficiency and minimise unwanted side effects. Targeted delivery could potentially be achieved with porous microparticles loaded with superparamagnetic iron oxide nanoparticles (SPIONs)—in combination with a target-directed magnetic gradient field. The aim of this study was to formulate and evaluate the aerodynamic properties of SPIONs-loaded Trojan microparticles after delivery from a dry powder inhaler. Microparticles made of SPIONs, PEG and hydroxypropyl-β-cyclodextrin (HPβCD) were formulated by spray drying and characterised by various physicochemical methods. Aerodynamic properties were evaluated using a next generation cascade impactor (NGI), with or without a magnet positioned at stage 2. Mixing appropriate proportions of SPIONs, PEG and HPβCD allowed Trojan microparticle to be formulated. These particles had a median geometric diameter of 2.8 ± 0.3 μm and were shown to be sensitive to the magnetic field induced by a magnet having a maximum energy product of 413.8 kJ/m3. However, these particles, characterised by a mass median aerodynamic diameter (MMAD) of 10.2 ± 2.0 μm, were considered to be not inhalable. The poor aerodynamic properties resulted from aggregation of the particles. The addition of (NH4)2CO3 and magnesium stearate (MgST) to the formulation improved the aerodynamic properties of the Trojan particles and resulted in a MMAD of 2.2 ± 0.8 μm. In the presence of a magnetic field on stage 2 of the NGI, the amount of particles deposited at this stage increased 4-fold from 4.8 ± 0.7% to 19.5 ± 3.3%. These Trojan particles appeared highly sensitive to the magnetic field and their deposition on most of the stages of the NGI was changed in the presence compared to the absence of the magnet. If loaded with a pharmaceutical active ingredient, these particles may be useful for treating localised lung disease such as cancer nodules or bacterial infectious foci.en
dc.format.extent98-104en
dc.language.isoenen
dc.relation.ispartofseriesEuropean journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.Ven
dc.relation.ispartofseries86en
dc.relation.ispartofseries1en
dc.rightsYen
dc.subjectNGIen
dc.subjectAerodynamicen
dc.subjectMagnetic targetingen
dc.subjectLungen
dc.subjectAerosolen
dc.subjectTrojan microparticlesen
dc.subjectSPIONen
dc.titleSuperparamagnetic iron oxide nanoparticles (SPIONs)-loaded Trojan microparticles for targeted aerosol delivery to the lungen
dc.typeJournal Articleen
dc.contributor.sponsorScience Foundation Ireland (SFI)en
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/healyamen
dc.identifier.rssinternalid98553en
dc.identifier.doihttp://dx.doi.org/10.1016/j.ejpb.2013.09.004en
dc.rights.ecaccessrightsopenAccess
dc.contributor.sponsorGrantNumber07/SRC/B1154en
dc.subject.TCDTagDrug development and evaluationen
dc.identifier.orcid_id0000-0001-5093-9786en


Files in this item

This item appears in the following Collection(s)

Show simple item record