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dc.contributor.authorGARAVAN, HUGHen
dc.date.accessioned2014-12-19T13:46:38Z
dc.date.available2014-12-19T13:46:38Z
dc.date.created2013en
dc.date.issued2013en
dc.date.submitted2013en
dc.identifier.citationConnolly, Colm G Bell, Ryan P Foxe, John J Garavan, Hugh, Dissociated grey matter changes with prolonged addiction and extended abstinence in cocaine users, PloS one, 8, 3, 2013, e59645 -en
dc.identifier.issn1932-6203en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/72728
dc.descriptionPUBLISHEDen
dc.description.abstractExtensive evidence indicates that current and recently abstinent cocaine abusers compared to drug-naïve controls have decreased grey matter in regions such as the anterior cingulate, lateral prefrontal and insular cortex. Relatively little is known, however, about the persistence of these deficits in long-term abstinence despite the implications this has for recovery and relapse. Optimized voxel based morphometry was used to assess how local grey matter volume varies with years of drug use and length of abstinence in a cross-sectional study of cocaine users with various durations of abstinence (1–102 weeks) and years of use (0.3–24 years). Lower grey matter volume associated with years of use was observed for several regions including anterior cingulate, inferior frontal gyrus and insular cortex. Conversely, higher grey matter volumes associated with abstinence duration were seen in non-overlapping regions that included the anterior and posterior cingulate, insular, right ventral and left dorsal prefrontal cortex. Grey matter volumes in cocaine dependent individuals crossed those of drug-naïve controls after 35 weeks of abstinence, with greater than normal volumes in users with longer abstinence. The brains of abstinent users are characterized by regional grey matter volumes, which on average, exceed drug-naïve volumes in those users who have maintained abstinence for more than 35 weeks. The asymmetry between the regions showing alterations with extended years of use and prolonged abstinence suggest that recovery involves distinct neurobiological processes rather than being a reversal of disease-related changes. Specifically, the results suggest that regions critical to behavioral control may be important to prolonged, successful, abstinence.en
dc.format.extente59645en
dc.language.isoenen
dc.publisherPublic Library of Scienceen
dc.relation.ispartofseriesPloS oneen
dc.relation.ispartofseries8en
dc.relation.ispartofseries3en
dc.rightsYen
dc.subjectAlcoholismen
dc.titleDissociated grey matter changes with prolonged addiction and extended abstinence in cocaine usersen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/garavanhen
dc.identifier.rssinternalid98451en
dc.rights.ecaccessrightsopenAccess


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