Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments.
Item Type:Journal Article
Citation:Haneklaus M, O'Neill LA, Coll RC, Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments., Current opinion in immunology, 25, 1, 2013, 40-45
The protein NLRP3 has emerged as a central regulator in the inflammatory process, being implicated directly in hereditary cryopyrinopathies, and indirectly in diseases such as gout, Type 2 diabetes and atherosclerosis. NLRP3 is an important regulator of caspase-1, the enzyme that processes the immature form of IL-1β into the active protein. The control of NLRP3 has therefore become a focus of research with evidence for redox regulation, ubiquitination and regulation by miRNA-223, kinases and calcium all emerging as controllers of NLRP3. As our knowledge expands the prospect for precise pharmacological targeting of NLRP3 will improve and could lead to substantial clinical utility.
Type of material:Journal Article
Series/Report no:Current opinion in immunology
Availability:Full text available
Subject (TCD):Immunology, Inflammation & Infection