Show simple item record

dc.contributor.authorO'NEILL, LUKEen
dc.date.accessioned2014-12-17T12:25:54Z
dc.date.available2014-12-17T12:25:54Z
dc.date.issued2013en
dc.date.submitted2013en
dc.identifier.citationCarpenter S, Aiello D, Atianand MK, Ricci EP, Gandhi P, Hall LL, Byron M, Monks B, Henry-Bezy M, Lawrence JB, O'Neill LA, Moore MJ, Caffrey DR, Fitzgerald KA, A long noncoding RNA mediates both activation and repression of immune response genes., Science (New York, N.Y.), 341, 6147, 2013, 789-92en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/72550
dc.descriptionPUBLISHEDen
dc.description.abstractAn inducible program of inflammatory gene expression is central to antimicrobial defenses. This response is controlled by a collaboration involving signal-dependent activation of transcription factors, transcriptional co-regulators, and chromatin-modifying factors. We have identified a long noncoding RNA (lncRNA) that acts as a key regulator of this inflammatory response. Pattern recognition receptors such as the Toll-like receptors induce the expression of numerous lncRNAs. One of these, lincRNA-Cox2, mediates both the activation and repression of distinct classes of immune genes. Transcriptional repression of target genes is dependent on interactions of lincRNA-Cox2 with heterogeneous nuclear ribonucleoprotein A/B and A2/B1. Collectively, these studies unveil a central role of lincRNA-Cox2 as a broad-acting regulatory component of the circuit that controls the inflammatory response.en
dc.format.extent789-92en
dc.language.isoenen
dc.relation.ispartofseriesScience (New York, N.Y.)en
dc.relation.ispartofseries341en
dc.relation.ispartofseries6147en
dc.rightsYen
dc.subjectImmune Systemen
dc.titleA long noncoding RNA mediates both activation and repression of immune response genes.en
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/laoneillen
dc.identifier.rssinternalid90847en
dc.identifier.doihttp://dx.doi.org/10.1126/science.1240925en
dc.rights.ecaccessrightsopenAccess
dc.subject.TCDThemeImmunology, Inflammation & Infectionen


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record