Show simple item record

dc.contributor.authorGARAVAN, HUGHen
dc.contributor.authorWHELAN, ROBERTen
dc.date.accessioned2014-12-11T11:54:25Z
dc.date.available2014-12-11T11:54:25Z
dc.date.issued2013en
dc.date.submitted2013en
dc.identifier.citationMontigny C, Castellanos-Ryan N, Whelan R, Banaschewski T, Barker GJ, Büchel C, Gallinat J, Flor H, Mann K, Paillère-Martinot ML, Nees F, Lathrop M, Loth E, Paus T, Pausova Z, Rietschel M, Schumann G, Smolka MN, Struve M, Robbins TW, Garavan H, Conrod PJ, A phenotypic structure and neural correlates of compulsive behaviors in adolescents., PloS one, 8, 11, 2013, e80151en
dc.identifier.issn1932-6203en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/72445
dc.descriptionPUBLISHEDen
dc.description.abstractBACKGROUND: A compulsivity spectrum has been hypothesized to exist across Obsessive-Compulsive disorder (OCD), Eating Disorders (ED), substance abuse (SA) and binge-drinking (BD). The objective was to examine the validity of this compulsivity spectrum, and differentiate it from an externalizing behaviors dimension, but also to look at hypothesized personality and neural correlates. METHOD: A community-sample of adolescents (N=1938; mean age 14.5 years), and their parents were recruited via high-schools in 8 European study sites. Data on adolescents' psychiatric symptoms, DSM diagnoses (DAWBA) and substance use behaviors (AUDIT and ESPAD) were collected through adolescent- and parent-reported questionnaires and interviews. The phenotypic structure of compulsive behaviors was then tested using structural equation modeling. The model was validated using personality variables (NEO-FFI and TCI), and Voxel-Based Morphometry (VBM) analysis. RESULTS: Compulsivity symptoms best fit a higher-order two factor model, with ED and OCD loading onto a compulsivity factor, and BD and SA loading onto an externalizing factor, composed also of ADHD and conduct disorder symptoms. The compulsivity construct correlated with neuroticism (r=0.638; p ≤ 0.001), conscientiousness (r=0.171; p ≤ 0.001), and brain gray matter volume in left and right orbitofrontal cortex, right ventral striatum and right dorsolateral prefrontal cortex. The externalizing factor correlated with extraversion (r=0.201; p ≤ 0.001), novelty-seeking (r=0.451; p ≤ 0.001), and negatively with gray matter volume in the left inferior and middle frontal gyri. CONCLUSIONS: Results suggest that a compulsivity spectrum exists in an adolescent, preclinical sample and accounts for variance in both OCD and ED, but not substance-related behaviors, and can be differentiated from an externalizing spectrum.en
dc.format.extente80151en
dc.language.isoenen
dc.relation.ispartofseriesPloS oneen
dc.relation.ispartofseries8en
dc.relation.ispartofseries11en
dc.rightsYen
dc.subjectAdolescentsen
dc.titleA phenotypic structure and neural correlates of compulsive behaviors in adolescents.en
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/garavanhen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/whelanr3en
dc.identifier.rssinternalid98328en
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0080151en
dc.rights.ecaccessrightsopenAccess


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record