Show simple item record

dc.date.accessioned2014-12-11T10:55:48Z
dc.date.available2014-12-11T10:55:48Z
dc.date.issued2014en
dc.date.submitted2014en
dc.identifier.citationF. Wetterling, L. Gallagher, J. Mullin, W.M. Holmes, C. McCabe, I.M. Macrae, A.J. Fagan, Sodium-23 Magnetic Resonance Imaging has potential for improving penumbra detection but not for estimating stroke onset time, Journal of Cerebral Blood Flow and Metabolism, 2014en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/72440
dc.descriptionPUBLISHEDen
dc.description.abstractTissue sodium concentration increases in irreversibly damaged (core) tissue following ischemic stroke and can potentially help to differentiate the core from the adjacent hypoperfused but viable penumbra. To test this, multinuclear hydrogen-1/sodium-23 magnetic resonance imaging (MRI) was used to measure the changing sodium signal and hydrogen-apparent diffusion coefficient (ADC) in the ischemic core and penumbra after rat middle cerebral artery occlusion (MCAO). Penumbra and core were defined from perfusion imaging and histologically defined irreversibly damaged tissue. The sodium signal in the core increased linearly with time, whereas the ADC rapidly decreased by >30% within 20 minutes of stroke onset, with very little change thereafter (0.5–6 hours after MCAO). Previous reports suggest that the time point at which tissue sodium signal starts to rise above normal (onset of elevated tissue sodium, OETS) represents stroke onset time (SOT). However, extrapolating core data back in time resulted in a delay of 72±24 minutes in OETS compared with actual SOT. At the OETS in the core, penumbra sodium signal was significantly decreased (88±6%, P=0.0008), whereas penumbra ADC was not significantly different (92±18%, P=0.2) from contralateral tissue. In conclusion, reduced sodium-MRI signal may serve as a viability marker for penumbra detection and can complement hydrogen ADC and perfusion MRI in the time-independent assessment of tissue fate in acute stroke patients.en
dc.language.isoenen
dc.relation.ispartofseriesJournal of Cerebral Blood Flow and Metabolismen
dc.rightsYen
dc.subjectSodium MRIen
dc.subjectStroke Onset Timeen
dc.subjectOnset of Elevated Tissue Sodiumen
dc.subjectPenumbraen
dc.titleSodium-23 Magnetic Resonance Imaging has potential for improving penumbra detection but not for estimating stroke onset timeen
dc.typeJournal Articleen
dc.contributor.sponsorScience Foundation Ireland (SFI)en
dc.contributor.sponsorScience Foundation Ireland (SFI)en
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/fagananen
dc.identifier.rssinternalid96734en
dc.identifier.doihttp://dx.doi.org/10.1038/jcbfm.2014.174en
dc.rights.ecaccessrightsopenAccess
dc.contributor.sponsorGrantNumber06/RFP/PHY006/STTF08en
dc.contributor.sponsorGrantNumber06/RFP/PHY006en
dc.subject.TCDThemeNeuroscienceen
dc.subject.TCDThemeNext Generation Medical Devicesen
dc.subject.TCDTagACUTE ISCHEMIC STROKEen
dc.subject.TCDTagMAGNETIC RESONANCE IMAGINGen
dc.subject.TCDTagMedical Devicesen
dc.subject.TCDTagSodium-MRIen
dc.identifier.rssurihttp://www.nature.com/jcbfm/journal/vaop/ncurrent/full/jcbfm2014174a.htmlen


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record