Citrullination as early-stage indicator of cell response to single-walled carbon nanotubes.
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2013Author:
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Mohamed BM, Movia D, Knyazev A, Langevin D, Davies AM, Prina-Mello A, Volkov Y, Citrullination as early-stage indicator of cell response to single-walled carbon nanotubes., Scientific reports, 3, 2013, 1124Download Item:
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Abstract:
Single-walled carbon nanotubes (SWCNTs) have been widely explored as potential technologies for
information systems and medical applications. The impact of SWCNTs on human health is of prime
concern, if SWCNTs have a future in the manufacturing industry. This study proposes a novel,
inflammation-independent paradigm of toxicity for SWCNTs, identifying the protein citrullination process
as early-stage indicator of inflammatory responses of macrophages (THP-1) and of subtle phenotypic
damages of lung epithelial (A549) cells following exposure to chemically-treated SWCNTs. Our results
showed that, while most of the cellular responses of A549 cells exposed to SWCNTs are different to those of
similarly treated THP-1 cells, the protein citrullination process is triggered in a dose- and time-dependent
manner in both cell lines, with thresholds comparable between inflammatory (THP-1) and
non-inflammatory (A549) cell types. The cellular mechanism proposed herein could have a high impact in
predicting the current risk associated with environmental exposure to SWCNTs
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http://people.tcd.ie/prinameaDescription:
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Author: PRINA MELLO, ADRIELE
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Scientific reports3
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Full text availableKeywords:
Single-walled carbon nanotubesSubject (TCD):
Immunology, Inflammation & Infection , Nanoscience & MaterialsDOI:
http://dx.doi.org/10.1038/srep01124ISSN:
2045-2322Licences: