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dc.contributor.authorO'REILLY, VINCENTen
dc.contributor.authorDOHERTY, DEREKen
dc.date.accessioned2014-12-02T11:52:01Z
dc.date.available2014-12-02T11:52:01Z
dc.date.issued2013en
dc.date.submitted2013en
dc.identifier.citationMangan BA, Dunne MR, O'Reilly VP, Dunne PJ, Exley MA, O'Shea D, Scotet E, Hogan AE, Doherty DG, Cutting edge: CD1d restriction and Th1/Th2/Th17 cytokine secretion by human V¿3 T cells., Journal of immunology (Baltimore, Md. : 1950), 191, 1, 2013, 30-4en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/72388
dc.descriptionPUBLISHEDen
dc.description.abstractHuman γδ T cells expressing the Vδ3 TCR make up a minor lymphocyte subset in blood but are enriched in liver and in patients with some chronic viral infections and leukemias. We analyzed the frequencies, phenotypes, restriction elements, and functions of fresh and expanded peripheral blood Vδ3 T cells. Vδ3 T cells accounted for ~0.2% of circulating T cells, included CD4(+), CD8(+), and CD4(-)CD8(-) subsets, and variably expressed CD56, CD161, HLA-DR, and NKG2D but neither NKG2A nor NKG2C. Vδ3 T cells were sorted and expanded by mitogen stimulation in the presence of IL-2. Expanded Vδ3 T cells recognized CD1d but not CD1a, CD1b, or CD1c. Upon activation, they killed CD1d(+) target cells, released Th1, Th2, and Th17 cytokines, and induced maturation of dendritic cells into APCs. Thus, Vδ3 T cells are glycolipid-reactive T cells with distinct Ag specificities but functional similarities to NKT cells.en
dc.format.extent30-4en
dc.language.isoenen
dc.relation.ispartofseriesJournal of immunology (Baltimore, Md. : 1950)en
dc.relation.ispartofseries191en
dc.relation.ispartofseries1en
dc.rightsYen
dc.subjectcytokine secretionen
dc.titleCutting edge: CD1d restriction and Th1/Th2/Th17 cytokine secretion by human V¿3 T cells.en
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/oreillven
dc.identifier.peoplefinderurlhttp://people.tcd.ie/dohertdeen
dc.identifier.rssinternalid89297en
dc.identifier.doihttp://dx.doi.org/10.4049/jimmunol.1300121en
dc.rights.ecaccessrightsopenAccess
dc.subject.TCDThemeImmunology, Inflammation & Infectionen
dc.subject.TCDThemeInternational Developmenten


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