Show simple item record

dc.contributor.authorMCGETTRICK-DILLON, ANNEen
dc.contributor.authorO'NEILL, LUKEen
dc.date.accessioned2014-12-01T14:21:00Z
dc.date.available2014-12-01T14:21:00Z
dc.date.issued2013en
dc.date.submitted2013en
dc.identifier.citationMcGettrick, A.F., O'Neill, L.A.J., How metabolism generates signals during innate immunity and inflammation, Journal of Biological Chemistry, 288, 32, 2013, 22893-22898en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/72337
dc.descriptionPUBLISHEDen
dc.description.abstractThe interplay between immunity, inflammation, and metabolic changes is a growing field of research. Toll-like receptors and NOD-like receptors are families of innate immune receptors, and their role in the human immune response is well documented. Exciting new evidence is emerging with regard to their role in the regulation of metabolism and the activation of inflammatory pathways during the progression of metabolic disorders such as type 2 diabetes and atherosclerosis. The proinflammatory cytokine IL-1β appears to play a central role in these disorders. There is also evidence that metabolites such as NAD+ (acting via deacetylases such as SIRT1 and SIRT2) and succinate (which regulates hypoxia-inducible factor 1α) are signals that regulate innate immunity. In addition, the extracellular overproduction of metabolites such as uric acid and cholesterol crystals acts as a signal sensed by NLRP3, leading to the production of IL-1β. These observations cast new light on the role of metabolism during host defense and inflammation.en
dc.format.extent22893-22898en
dc.language.isoenen
dc.relation.ispartofseriesJournal of Biological Chemistryen
dc.relation.ispartofseries288en
dc.relation.ispartofseries32en
dc.rightsYen
dc.subjectSignal Transductionen
dc.subjectMetabolism,en
dc.subjectMetabolic Regulationen
dc.subjectMetabolic Diseasesen
dc.subjectInnate Immunity,en
dc.subjectInflammationen
dc.titleHow metabolism generates signals during innate immunity and inflammationen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/laoneillen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/mcgettraen
dc.identifier.rssinternalid90846en
dc.identifier.doihttp://dx.doi.org/10.1074/jbc.R113.486464en
dc.rights.ecaccessrightsopenAccess
dc.subject.TCDThemeImmunology, Inflammation & Infectionen


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record