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dc.contributor.authorHICKEY, FIONNUALAen
dc.date.accessioned2014-10-14T10:46:04Z
dc.date.available2014-10-14T10:46:04Z
dc.date.issued2009en
dc.date.submitted2009en
dc.identifier.citationRyan A, Murphy M, Godson C, Hickey FB, Diabetes mellitus and apoptosis:inflammatory cells, Apoptosis, 14, 12, 2009en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/71504
dc.descriptionPUBLISHEDen
dc.description.abstractSince the early observation that similarities between thyroiditis and insulitis existed, the important role played by inflammation in the development of diabetes has been appreciated. More recently, experiments have shown that inflammation also plays a prominent role in the development of target organ damage arising as complications, with both elements of the innate and the adaptive immune system being involved, and that cytokines contributing to local tissue damage may arise from both infiltrating and resident cells. This review will discuss the experimental evidence that shows that inflammatory cell-mediated apoptosis contributes to target organ damage, from beta cell destruction to both micro- and macro-vascular disease complications, and also how alterations in leukocyte turnover affects immune function.en
dc.language.isoenen
dc.relation.ispartofseriesApoptosisen
dc.relation.ispartofseries14en
dc.relation.ispartofseries12en
dc.rightsYen
dc.subjectDiabetesen
dc.subjectMicrovascular complicationsen
dc.subjectMacrovascular complicationsen
dc.subjectApoptosisen
dc.subjectInflammationen
dc.titleDiabetes mellitus and apoptosis:inflammatory cellsen
dc.typeReviewen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/hickeyfben
dc.identifier.rssinternalid88627en
dc.rights.ecaccessrightsopenAccess
dc.identifier.rssurihttp://link.springer.com/article/10.1007%2Fs10495-009-0340-zen


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