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dc.contributor.authorDONOHOE, GARYen
dc.date.accessioned2014-10-01T12:47:40Z
dc.date.available2014-10-01T12:47:40Z
dc.date.issued2013en
dc.date.submitted2013en
dc.identifier.citationThong JY, Qiu A, Sum MY, Kuswanto CN, Tuan TA, Donohoe G, Sitoh YY, Sim K., Effects of the neurogranin variant rs12807809 on thalamocortical morphology in schizophrenia., PLoS One., 8, 12, 2013, e85603.en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/71422
dc.descriptionPUBLISHEDen
dc.description.abstractAlthough the genome wide supported psychosis susceptibility neurogranin (NRGN) gene is expressed in human brains, it is unclear how it impacts brain morphology in schizophrenia. We investigated the influence of NRGN rs12807809 on cortical thickness, subcortical volumes and shapes in patients with schizophrenia. One hundred and fifty six subjects (91 patients with schizophrenia and 65 healthy controls) underwent structural MRI scans and their blood samples were genotyped. A brain mapping algorithm, large deformation diffeomorphic metric mapping, was used to perform group analysis of subcortical shapes and cortical thickness. Patients with risk TT genotype were associated with widespread cortical thinning involving frontal, parietal and temporal cortices compared with controls with TT genotype. No volumetric difference in subcortical structures (hippocampus, thalamus, amygdala, basal ganglia) was observed between risk TT genotype in patients and controls. However, patients with risk TT genotype were associated with thalamic shape abnormalities involving regions related to pulvinar and medial dorsal nuclei. Our results revealed the influence of the NRGN gene on thalamocortical morphology in schizophrenia involving widespread cortical thinning and thalamic shape abnormalities. These findings help to clarify underlying NRGN mediated pathophysiological mechanisms involving cortical-subcortical brain networks in schizophreniaen
dc.format.extente85603.en
dc.language.isoenen
dc.relation.ispartofseriesPLoS One.en
dc.relation.ispartofseries8en
dc.relation.ispartofseries12en
dc.rightsYen
dc.subjectCentral nervous systemen
dc.subjectDeformationen
dc.subjectHippocampusen
dc.subjectSchizophreniaen
dc.subjectThalamic nucleien
dc.subjectThalamusen
dc.titleEffects of the neurogranin variant rs12807809 on thalamocortical morphology in schizophrenia.en
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/donoghugen
dc.identifier.rssinternalid96905en
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0085603en
dc.rights.ecaccessrightsopenAccess


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