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dc.contributor.authorBARR, MARTINen
dc.contributor.authorGATELY, KATHYen
dc.contributor.authorO'BYRNE, KENen
dc.date.accessioned2014-09-08T14:33:31Z
dc.date.available2014-09-08T14:33:31Z
dc.date.issued2013en
dc.date.submitted2013en
dc.identifier.citationGodwin P, Baird AM, Heavey S, Barr MP, O'Byrne KJ, Gately K., Targeting nuclear factor-kappa B to overcome resistance to chemotherapy., Frontiers in oncology, 3, 2013, 120en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/71225
dc.descriptionPUBLISHEDen
dc.description.abstractIntrinsic or acquired resistance to chemotherapeutic agents is a common phenomenon and a major challenge in the treatment of cancer patients. Chemoresistance is defined by a complex network of factors including multi-drug resistance proteins, reduced cellular uptake of the drug, enhanced DNA repair, intracellular drug inactivation, and evasion of apoptosis. Pre-clinical models have demonstrated that many chemotherapy drugs, such as platinum-based agents, antracyclines, and taxanes, promote the activation of the NF-κB pathway. NF-κB is a key transcription factor, playing a role in the development and progression of cancer and chemoresistance through the activation of a multitude of mediators including anti-apoptotic genes. Consequently, NF-κB has emerged as a promising anti-cancer target. Here, we describe the role of NF-κB in cancer and in the development of resistance, particularly cisplatin. Additionally, the potential benefits and disadvantages of targeting NF-κB signaling by pharmacological intervention will be addressed.en
dc.format.extent120en
dc.language.isoenen
dc.relation.ispartofseriesFrontiers in oncologyen
dc.relation.ispartofseries3en
dc.rightsYen
dc.subjectoncogeneen
dc.subjectapoptosisen
dc.subjectresistanceen
dc.subjectchemotherapyen
dc.subjectcisplatinen
dc.subjectcanceren
dc.subjectNF-κBen
dc.titleTargeting nuclear factor-kappa B to overcome resistance to chemotherapy.en
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/obyrnekeen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/barrmaen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/gatelyken
dc.identifier.rssinternalid96237en
dc.identifier.doihttp://dx.doi.org/10.3389/fonc.2013.00120en
dc.rights.ecaccessrightsopenAccess
dc.subject.TCDThemeCanceren
dc.subject.TCDTagBiomedical sciencesen


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