dc.contributor.author | CUNNINGHAM, COLM | en |
dc.date.accessioned | 2014-08-06T10:25:44Z | |
dc.date.available | 2014-08-06T10:25:44Z | |
dc.date.issued | 2011 | en |
dc.date.submitted | 2011 | en |
dc.identifier.citation | Colm Cunningham, Systemic inflammation and delirium: important co-factors in the progression of dementia, Biochemical Society Transactions, 39, 2011, 945 - 953 | en |
dc.identifier.other | Y | en |
dc.identifier.uri | http://hdl.handle.net/2262/70690 | |
dc.description | PUBLISHED | en |
dc.description.abstract | It is widely accepted that inflammation plays some role in the progression of chronic neurodegenerative
diseases such as AD (Alzheimer’s disease), but its precise role remains elusive. It has been known for many
years that systemic inflammatory insults can signal to the brain to induce changes in CNS (central nervous
system) function, typically grouped under the syndrome of sickness behaviour. These changes are mediated
via systemic and CNS cytokine and prostaglandin synthesis. When patients with dementia suffer similar
systemic inflammatory insults, delirium is a frequent consequence. This profound and acute exacerbation of
cognitivedysfunctionisassociatedwithpoorprognosis:acceleratingcognitivedeclineandshorteningtimeto
permanent institutionalization and death. Therefore a better understanding of how delirium occurs during
dementia and how these episodes impact on existing neurodegeneration are now important priorities.
The current review summarizes the relationship between dementia, systemic inflammation and episodes of
delirium and addresses the basic scientific approaches currently being pursued with respect to understanding
acute cognitive dysfunction during aging and dementia. In addition, despite there being limited studies on
this subject, it is becoming increasingly clear that infections and other systemic inflammatory conditions
do increase the risk of AD and accelerate the progression of established dementia. These data suggest that
systemic inflammation is a major contributor to the progression of dementia and constitutes an important
clinical target | en |
dc.format.extent | 945 | en |
dc.format.extent | 953 | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | Biochemical Society Transactions | en |
dc.relation.ispartofseries | 39 | en |
dc.rights | Y | en |
dc.subject | Dementia | en |
dc.title | Systemic inflammation and delirium: important co-factors in the progression of dementia | en |
dc.contributor.sponsor | Wellcome Trust | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/cunninco | en |
dc.identifier.rssinternalid | 74338 | en |
dc.identifier.doi | http://dx.doi.org/10.1042/BST0390945 | en |
dc.rights.ecaccessrights | openAccess | |
dc.subject.TCDTheme | Ageing | en |
dc.subject.TCDTheme | Immunology, Inflammation & Infection | en |
dc.subject.TCDTheme | Neuroscience | en |
dc.identifier.orcid_id | 0000-0003-1423-5209 | en |