Show simple item record

dc.contributor.authorGILL, MICHAELen
dc.date.accessioned2014-06-03T15:23:38Z
dc.date.available2014-06-03T15:23:38Z
dc.date.issued2011en
dc.date.submitted2011en
dc.identifier.citationHollingsworth P, Harold D, Sims R, Gerrish A, Lambert JC, Carrasquillo MM, Abraham R, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Jones N, Stretton A, Thomas C, Richards A, Ivanov D et al., Common Variants at ABCA7, MS4A6A/MS4A4E, EPHA1/CD33 and CD2AP are associated with Alzheimer's disease, Nature Genetics, 43, 5, 2011, 429-436en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/69587
dc.descriptionPUBLISHEDen
dc.descriptionPMID: 21460840en
dc.description.abstractWe sought to identify new susceptibility loci for Alzheimer's disease through a staged association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease Genetic Consortium (ADGC) in a companion paper. We undertook a combined analysis of four genome-wide association datasets (stage 1) and identified ten newly associated variants with P ≤ 1 × 10(-5). We tested these variants for association in an independent sample (stage 2). Three SNPs at two loci replicated and showed evidence for association in a further sample (stage 3). Meta-analyses of all data provided compelling evidence that ABCA7 (rs3764650, meta P = 4.5 × 10(-17); including ADGC data, meta P = 5.0 × 10(-21)) and the MS4A gene cluster (rs610932, meta P = 1.8 × 10(-14); including ADGC data, meta P = 1.2 × 10(-16)) are new Alzheimer's disease susceptibility loci. We also found independent evidence for association for three loci reported by the ADGC, which, when combined, showed genome-wide significance: CD2AP (GERAD+, P = 8.0 × 10(-4); including ADGC data, meta P = 8.6 × 10(-9)), CD33 (GERAD+, P = 2.2 × 10(-4); including ADGC data, meta P = 1.6 × 10(-9)) and EPHA1 (GERAD+, P = 3.4 × 10(-4); including ADGC data, meta P = 6.0 × 10(-10)).en
dc.format.extent429-436en
dc.language.isoenen
dc.relation.ispartofseriesNature Geneticsen
dc.relation.ispartofseries43en
dc.relation.ispartofseries5en
dc.rightsYen
dc.subjectAlzheimer's Diseaseen
dc.titleCommon Variants at ABCA7, MS4A6A/MS4A4E, EPHA1/CD33 and CD2AP are associated with Alzheimer's diseaseen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/mgillen
dc.identifier.rssinternalid73113en
dc.identifier.doihttp://dx.doi.org/10.1038/ng.803en
dc.rights.ecaccessrightsopenAccess
dc.subject.TCDThemeGenes & Societyen


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record