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dc.contributor.authorGILL, MICHAELen
dc.contributor.authorHAWI, ZIARIHen
dc.date.accessioned2014-06-03T14:30:01Z
dc.date.available2014-06-03T14:30:01Z
dc.date.issued2011en
dc.date.submitted2011en
dc.identifier.citationSegurado R, Bellgrove A, Mancone F, Gill M, Hawi Z, Epistasis between neurochemical gene polymorphisms and risk for ADHD, European Journal of Human Genetics, 19, 5, 2011, 577-582en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/69586
dc.descriptionPUBLISHEDen
dc.descriptionPMID: 21368917en
dc.description.abstractA number of genes with function related to synaptic neurochemistry have been genetically associated with attention deficit/hyperactivity disorder. However, susceptibility to the development of common psychiatric disorders by single variants acting alone, can so far only explain a small proportion of the heritability of the phenotype. It has been postulated that the unexplained 'dark heritability' may at least in part be due to epistatic effects, which may account for the small observed marginal associations, and the difficulties with replication of positive findings. We undertook a comprehensive exploration of pair-wise interactions between genetic variants in 24 candidate genic regions involved in monoaminergic catabolism, anabolism, release, re-uptake and signal transmission in a sample of 177 parent-affected child trios using a case-only design and a case-pseudocontrol design using conditional logistic regression. Marker-pairs thresholded on interaction odds ratio (OR) and P-value are presented. We detected a number of interaction ORs >4.0, including an interesting correlation between markers in the ADRA1B and DBH genes in affected individuals, and several further interesting but smaller effects. These effects are no larger than you would expect by chance under the assumption of independence of all pair-wise relations; however, independence is unlikely. Furthermore, the size of these effects is of interest and attempts to replicate these results in other samples are anticipateden
dc.format.extent577-582en
dc.language.isoenen
dc.relation.ispartofseriesEuropean Journal of Human Geneticsen
dc.relation.ispartofseries19en
dc.relation.ispartofseries5en
dc.rightsYen
dc.subjectPsychiatryen
dc.titleEpistasis between neurochemical gene polymorphisms and risk for ADHDen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/mgillen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/zhhawien
dc.identifier.rssinternalid73112en
dc.identifier.doihttp://dx.doi.org/10.1038/ejhg.2010.250en
dc.rights.ecaccessrightsopenAccess
dc.subject.TCDThemeGenes & Societyen


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