Show simple item record

dc.contributor.authorMORAN, GARYen
dc.date.accessioned2014-05-19T14:52:31Z
dc.date.available2014-05-19T14:52:31Z
dc.date.issued2012en
dc.date.submitted2012en
dc.identifier.citationHiggins J, Pinjon E, Oltean HN, White TC, Kelly SL, Martel CM, Sullivan DJ, Coleman DC and Moran GP, Triclosan antagonises fluconazole activity against Candida albicans, Journal of Dental Research, 91, 1, 2012, 65 - 70en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/69260
dc.descriptionPUBLISHEDen
dc.descriptionEpub October 4th 2011en
dc.description.abstractTriclosan is a broad-spectrum antimicrobial compound commonly used in oral hygiene products. Investigation of its activity against Candida albicans showed that triclosan was fungicidal at concentrations of 16 mg/L. However, at subinhibitory concentrations (0.5-2 mg/L) triclosan antagonized the activity of fluconazole. Although triclosan induced CDR1 expression in C. albicans, antagonism was still observed in cdr1? and cdr2? strains. Triclosan did not affect fluconazole uptake or alter total membrane sterol content, but did induce the expression of FAS1 and FAS2, indicating that its mode of action may involve inhibition of fatty acid synthesis, as it does in prokaryotes. However, FAS2 mutants did not exhibit increased susceptibility to triclosan and overexpression of both FAS1 and FAS2 alleles did not alter triclosan susceptibility. Unexpectedly, the antagonistic effect was specific for C. albicans under hypha inducing conditions and was absent in the nonfilamentous efg1? strain. This antagonism may be due to the membranotropic activity of triclosan and the unique compostion of hyphal membranes.en
dc.description.sponsorshipHealth Research Boarden
dc.format.extent65en
dc.format.extent70en
dc.language.isoenen
dc.relation.ispartofseriesJournal of Dental Researchen
dc.relation.ispartofseries91en
dc.relation.ispartofseries1en
dc.rightsYen
dc.subjectCandida albicansen
dc.subjecttriclosanen
dc.subjectfluconazoleen
dc.subjectEFG1en
dc.titleTriclosan antagonises fluconazole activity against Candida albicansen
dc.typeJournal Articleen
dc.contributor.sponsorHealth Research Board (HRB)en
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/gmoranen
dc.identifier.rssinternalid74754en
dc.contributor.sponsorGrantNumberRP/2002/6en
dc.subject.TCDThemeGenes & Societyen
dc.subject.TCDThemeImmunology, Inflammation & Infectionen
dc.identifier.orcid_id0000-0003-0469-1788en


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record