Browsing Microbiology by Author "GEOGHEGAN, JOAN"
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Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus
GEOGHEGAN, JOAN; FOSTER, TIMOTHY (2014)Staphylococcus aureus is an important opportunistic pathogen and persistently colonizes about 20% of the human population. Its surface is 'decorated' with proteins that are covalently anchored to the cell wall peptidoglycan. ... -
Clumping factor A interaction with complement factor I increases C3b cleavage on the bacterial surface of Staphylococcus aureus, and decreases complement-mediated phagocytosis
FOSTER, TIMOTHY; GEOGHEGAN, JOAN (2010)The human complement system is important in the immunological control of Staphylococcus aureus infection. We showed previously that S. aureus surface protein clumping factor A (ClfA), when expressed in recombinant form, ... -
Clumping factor B promotes adherence of Staphylococcus aureus to corneocytes in atopic dermatitis
IRVINE, ALAN; GEOGHEGAN, JOAN; FOSTER, TIMOTHY; FALLON, PADRAIC (2017) -
Complement regulator C4BP binds to Staphylococcus aureus surface proteins SdrE and Bbp inhibiting bacterial opsonization and killing.
GEOGHEGAN, JOAN; FOSTER, TIMOTHY (2013)Staphylococcus aureus is a premier human pathogen and the most common cause of osteoarticular, wound, and implanted device infections. We recently demonstrated S. aureus efficiently binds the classical complement regulator ... -
Direct interaction of iron-regulated surface determinant IsdB of Staphylococcus aureus with the GPIIb/IIIa receptor on platelets
FOSTER, TIMOTHY; GEOGHEGAN, JOAN (2010) -
Emergence of the Epidemic Methicillin-Resistant Staphylococcus aureus Strain USA300 Coincides with Horizontal Transfer of the Arginine Catabolic Mobile Element and speG-mediated Adaptations for Survival on Skin.
GEOGHEGAN, JOAN (2013)The arginine catabolic mobile element (ACME) is the largest genomic region distinguishing epidemic USA300 strains of methicillin-resistant Staphylococcus aureus (MRSA) from other S. aureus strains. However, the functional ... -
Fibronectin binding proteins are required for biofilm formation by community-associated methicillin resistant Staphylococcus aureus strain LAC
GEOGHEGAN, JOAN (2014)Community-associated methicillin-resistant Staphylococcus aureus of the USA300 lineage is emerging as an important cause of medical device-related infection. However, few factors required for biofilm accumulation by USA300 ... -
Fibronectin Binding Proteins SpsD and SpsL Both Support Invasion of Canine Epithelial Cells by Staphylococcus pseudintermedius
GEOGHEGAN, JOAN; FOSTER, TIMOTHY (2015)In this study, we investigated the cell wall-anchored fibronectin-binding proteins SpsD and SpsL from the canine commensal and pathogen Staphylococcus pseudintermedius for their role in promoting bacterial invasion of ... -
Functional analysis of a murine monoclonal antibody against the repetitive region of the fibronectin-binding adhesins fibronectin-binding protein A and fibronectin-binding protein B from Staphylococcus aureus.
FOSTER, TIMOTHY JAMES; GEOGHEGAN, JOAN (2010)Fibronectin-binding proteins A and B are multifunctional LPXTG staphylococcal adhesins, comprising an N-terminal region that binds fibrinogen and elastin, and a C-terminal domain that interacts with fibronectin. The ... -
Genome sequence of Staphylococcus lugdunensis N920143 allows identification of putative colonization and virulence factors.
GEOGHEGAN, JOAN; FOSTER, TIMOTHY (2011) -
The immune evasion protein Sbi of Staphylococcus aureus occurs both extracellularly and anchored to the cell envelope by binding lipoteichoic acid
GEOGHEGAN, JOAN; FOSTER, TIMOTHY (2012)The Sbi protein of Staphylococcus aureus comprises two IgG binding domains similar to those of protein A and a region that triggers the activation of complement C3. Sbi is expressed on the cell surface but its C-terminal ... -
IsdC from Staphylococcus lugdunensis Induces Biofilm Formation under Low-Iron Growth Conditions.
GEOGHEGAN, JOAN; FOSTER, TIMOTHY (2014) -
Molecular characterization of the interaction of staphylococcal microbial surface components recognizing adhesive matrix molecules (MSCRAMMS) ClfA and Fbl with fibrinogen
GEOGHEGAN, JOAN; FOSTER, TIMOTHY JAMES (2010)The ligand binding domain of the fibrinogen binding protein from Staphylococcus lugdunensis (Fbl) shares 60% sequence identity with clumping factor A (ClfA) of Staphylococcus aureus. Recombinant Fbl corresponding to the ... -
Molecular Interactions of Human Plasminogen with Fibronectin-binding Protein B (FnBPB), a Fibrinogen/Fibronectin-binding Protein from Staphylococcus aureus.
GEOGHEGAN, JOAN; FOSTER, TIMOTHY (2016)Staphylococcus aureus is a commensal bacterium that has the ability to cause superficial and deep-seated infections. Like several other invasive pathogens, S. aureus can capture plasminogen from the human host where it can ... -
Nasal Colonisation by Staphylococcus aureus Depends upon Clumping Factor B Binding to the Squamous Epithelial Cell Envelope Protein Loricrin.
GEOGHEGAN, JOAN; MCLOUGHLIN, RACHEL; FOSTER, TIMOTHY (2012)Staphylococcus aureus asymptomatically colonises the anterior nares, but the host and bacterial factors that facilitate colonisation remain incompletely understood. The S. aureus surface protein ClfB has been shown to ... -
Protein-based biofilm matrices in Staphylococci.
FOSTER, TIMOTHY; GEOGHEGAN, JOAN (2014)Staphylococcus aureus and Staphylococcus epidermidis are the most important etiological agents of biofilm associated-infections on indwelling medical devices. Biofilm infections may also develop independently of indwelling ... -
Role for the A domain of unprocessed accumulation-associated protein (Aap) in the attachment phase of the Staphylococcus epidermidis biofilm phenotype
FOSTER, TIMOTHY; GEOGHEGAN, JOAN (2014)The polysaccharide intercellular adhesin or the cell wall-anchored accumulation-associated protein (Aap) mediates cellular accumulation during Staphylococcus epidermidis biofilm maturation. Mutation of sortase, which anchors ... -
Role of surface protein SasG in biofilm formation by Staphylococcus aureus.
GEOGHEGAN, JOAN; FOSTER, TIMOTHY (2010) -
A short sequence within subdomain N1 of region A of the Staphylococcus aureus MSCRAMM clumping factor A is required for export and surface display.
GEOGHEGAN, JOAN; FOSTER, TIMOTHY (2014)