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dc.contributor.authorBOWIE, ANDREWen
dc.date.accessioned2014-02-13T15:10:52Z
dc.date.available2014-02-13T15:10:52Z
dc.date.issued2011en
dc.date.submitted2011en
dc.identifier.citationKeating, S.E., Baran, M & Bowie, A.G., Cytosolic DNA sensors regulating type I interferon induction, Trends in Immunology, 32, 2011, 574 - 581en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/68041
dc.descriptionPUBLISHEDen
dc.description.abstractType I interferon induction is a critical anti-pathogen response mediated by innate immune stimulation. While it has been appreciated for some time that the presence of pathogen DNA within a cell leads to a type I interferon response, it is only in the past few years that some of the key signalling proteins and DNA sensors that regulate this response have been uncovered. Here we review the nature of these DNA sensors, which includes a new family of pattern recognition receptors termed the `AIM2-like receptors (ALRs), and consider the implications of their discovery for understanding emerging principles of innate immune DNA sensing. Furthermore, we discuss how their discovery provides a rationale as to why accumulation of self-DNA mediates IFN-dependent autoimmunity.en
dc.description.sponsorshipSFIen
dc.format.extent574en
dc.format.extent581en
dc.language.isoenen
dc.relation.ispartofseriesTrends in Immunologyen
dc.relation.ispartofseries32en
dc.rightsYen
dc.subjectType I interferon inductionen
dc.titleCytosolic DNA sensors regulating type I interferon inductionen
dc.typeJournal Articleen
dc.contributor.sponsorScience Foundation Ireland (SFI)en
dc.contributor.sponsorHealth Research Board (HRB)en
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/agbowieen
dc.identifier.rssinternalid75177en
dc.identifier.doihttp://dx.doi.org/10.1016/j.it.2011.08.004en
dc.rights.ecaccessrightsOpenAccess
dc.subject.TCDThemeImmunology, Inflammation & Infectionen
dc.identifier.orcid_id0000-0001-5316-4373en


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