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dc.contributor.authorLAVELLE, EDWARDen
dc.contributor.authorSCANLAN, EOINen
dc.date.accessioned2014-01-28T10:31:09Z
dc.date.available2014-01-28T10:31:09Z
dc.date.issued2014en
dc.date.submitted2014en
dc.identifier.citationBourke J, Brereton CF, Gordon SV, Lavelle EC and Scanlan EM, The Synthesis and Biological Evaluation of Mycobacterial p-Hydroxybenzoic Acid Derivatives (p-HBADs), Organic & Biomolecular Chemistry, 12, 7, 2014, 1114-1123en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/67910
dc.descriptionPUBLISHEDen
dc.descriptionPMID: 24424275en
dc.description.abstractMycobacterium tuberculosis establishes chronic infection and causes disease through manipulation of the host's innate and adaptive immune response. The bacterial cell wall is highly complex and contains a rich variety of glycosylated compounds that are secreted during infection and have been proposed as immunomodulatory molecules. Amongst the most important of these are the p-hydroxybenzoic acid derivatives (p-HBADs). Here we report the synthesis of this important class of biomolecules and the first in vitro study of the immunomodulatory effects of these compounds in isolation from the host bacterium. The compounds do not have stimulatory properties but, in contrast, can inhibit the production of inflammatory cytokines, particularly interferon-? (IFN-?), by T-cells. This study offers a fundamental insight into the effect of these glycans on the immune response.en
dc.format.extent1114-1123en
dc.language.isoenen
dc.relation.ispartofseriesOrganic & Biomolecular Chemistryen
dc.relation.ispartofseries12en
dc.relation.ispartofseries7en
dc.rightsYen
dc.subjectTuberculosisen
dc.titleThe Synthesis and Biological Evaluation of Mycobacterial p-Hydroxybenzoic Acid Derivatives (p-HBADs)en
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/lavelleeen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/scanlaeen
dc.identifier.rssinternalid91077en
dc.rights.ecaccessrightsOpenAccess
dc.subject.TCDThemeImmunology, Inflammation & Infectionen


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