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dc.contributor.authorSHORE, ANNAen
dc.contributor.authorCOLEMAN, DAVIDen
dc.date.accessioned2014-01-07T17:00:43Z
dc.date.available2014-01-07T17:00:43Z
dc.date.issued2013en
dc.date.submitted2013en
dc.identifier.citationSHORE AC, COLEMAN DC, STAPHYLOCOCCAL CASSETTE CHROSOMOME MEC: RECENT ADVANCES AND NEW INSIGHTS, INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, 303, 6-7, 2013, 350 - 359en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/67780
dc.descriptionPUBLISHEDen
dc.description13 March; Epub ahead of printen
dc.description.abstractStaphylococcal cassette chromosome (SCC) elements are complex mobile genetic elements that often carry antimicrobial resistance and in some cases virulence-associated genes. In addition to SCCmec, which harbours the methicillin resistance gene mec, many different SCC elements have been identified in staphylococci. Recent findings have significantly enhanced our understanding of the diversity of SCCmec elements and their contribution to the evolution of MRSA and are the focus of this short review. This includes the identification of (i) novel mec genes and allelic variants, (ii) an extensive array of ccr and mec complex genes as well as SCCmec, SCC and pseudo SCC/SCCmec elements and composite islands (CIs) in staphylococci, (iii) potential mec, SCC and SCCmec precursors among distinct coagulase-negative staphylococcal species, and (iv) SCC encoded virulence-associated genes. Due to their complex nature and increasing diversity, detailed characterisation of SCC and SCCmec elements and CIs represents a unique challenge but is vital for effective epidemiological typing and tracking of MRSA and other staphylococci and to enhance our understanding of the origins and evolution of MRSA.en_US
dc.description.sponsorshipMicrobiology Research Unit, Dublin Dental University Hospitalen_US
dc.format.extent350en
dc.format.extent359en
dc.language.isoenen_US
dc.relation.ispartofseriesINTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGYen
dc.relation.ispartofseries303en
dc.relation.ispartofseries6-7en
dc.rightsYen
dc.subjectSCCmecen_US
dc.subjectSCCmecen_US
dc.subjectMRSAen_US
dc.subjectcoagulase-negative staphylococcien_US
dc.subjectcomposite islandsen_US
dc.subjectmecAen_US
dc.subjectmecCen_US
dc.titleSTAPHYLOCOCCAL CASSETTE CHROSOMOME MEC: RECENT ADVANCES AND NEW INSIGHTSen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/dcolemanen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/ashoreen
dc.identifier.rssinternalid83730en
dc.identifier.doihttp://dx.doi.org/10.1016/j.ijmm.2013.02.002en
dc.rights.ecaccessrightsOpenAccess
dc.subject.TCDThemeImmunology, Inflammation & Infectionen
dc.identifier.rssurihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=23499303&dopt=Abstracten
dc.identifier.orcid_id0000-0003-1797-2888en


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