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dc.contributor.authorMCMANUS, BRENDAen
dc.contributor.authorCOLEMAN, DAVIDen
dc.date.accessioned2014-01-07T16:43:37Z
dc.date.available2014-01-07T16:43:37Z
dc.date.issued2013en
dc.date.submitted2013en
dc.identifier.citationABDULRAHIM MH, McMANUS BA, FLINT SR, COLEMAN DC, GENOTYPING Candida albicans FROM CANDIDA LEUKOPLAKIA AND NON-CANDIDA LEUKOPLAKIA SHOWS NO ENRICHMENT OF MULTILOCUS SEQUENCE TYPING CLADES BUT ENRICHMENT OF ABC GENOTYPE C IN CANDIDA LEUKOPLAKIA, PLOS ONE, 8, 9, 2013, 1-11:e73738en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/67779
dc.descriptionPUBLISHEDen
dc.descriptionPublished: September 18th 2013en
dc.description.abstractOral leukoplakias are histopathologically-diagnosed as Candida leukoplakia or non-Candida leukoplakia by the presence or absence of hyphae in the superficial epithelium. Candida leukoplakia lesions have significantly increased malignant potential. Candida albicans is the most prevalent fungal species associated with oral leukoplakia and may contribute to malignant transformation of Candida leukoplakia. To date, no detailed population analysis of C. albicans isolates from oral leukoplakia patients has been undertaken. This study investigated whether specific C. albicans genotypes were associated with Candida leukoplakia and non-Candida leukoplakia in a cohort of Irish patients. Patients with histopathologically-defined Candida leukoplakia (n=31) or non-Candida leukoplakia (n=47) were screened for Candida species by culture of oral rinse and lesional swab samples. Selected C. albicans isolates from Candida leukoplakia patients (n=25), non-Candida leukoplakia patients (n=19) and oral carriage isolates from age and sex matched healthy subjects without leukoplakia (n=34) were subjected to multilocus sequence typing (MLST) and ABC genotyping. MLST revealed that the clade distribution of C. albicans from both Candida leukoplakia and non-Candida leukoplakia lesions overlapped with the corresponding clade distributions of oral carriage isolates and global reference isolates from the MLST database indicating no enrichment of leukoplakia-associated clones. Oral leukoplakia isolates were significantly enriched with ABC genotype C (12/44, 27.3%), particularly Candida leukoplakia isolates (9/25, 36%), relative to oral carriage isolates (3/34, 8.8%). Genotype C oral leukoplakia isolates were distributed in MLST clades 1,3,4,5,8,9 and 15, whereas genotype C oral carriage isolates were distributed in MLST clades 4 and 11.en_US
dc.description.sponsorshipMicrobiology Research Unit, Dublin Dental University Hospitalen_US
dc.format.extent1-11:e73738en
dc.language.isoenen_US
dc.relation.ispartofseriesPLOS ONEen
dc.relation.ispartofseries8en
dc.relation.ispartofseries9en
dc.rightsYen
dc.subjectCandida leukoplakiaen_US
dc.subjectMLSTen_US
dc.subjectABC genotypingen_US
dc.subjectCandida albicansen_US
dc.titleGENOTYPING Candida albicans FROM CANDIDA LEUKOPLAKIA AND NON-CANDIDA LEUKOPLAKIA SHOWS NO ENRICHMENT OF MULTILOCUS SEQUENCE TYPING CLADES BUT ENRICHMENT OF ABC GENOTYPE C IN CANDIDA LEUKOPLAKIAen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/dcolemanen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/bmcmanuen
dc.identifier.rssinternalid88464en
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0073738en
dc.rights.ecaccessrightsOpenAccess
dc.subject.TCDThemeImmunology, Inflammation & Infectionen
dc.identifier.rssurihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=24058485&dopt=Abstracten
dc.identifier.orcid_id0000-0003-1797-2888en


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