dc.contributor.author | LAVELLE, EDWARD | en |
dc.contributor.author | MILLS, KINGSTON | en |
dc.contributor.author | LALOR, STEPHEN | en |
dc.date.accessioned | 2013-11-15T12:52:11Z | |
dc.date.available | 2013-11-15T12:52:11Z | |
dc.date.issued | 2009 | en |
dc.date.submitted | 2009 | en |
dc.identifier.citation | Sutton, C.E., Lalor, S.J., Sweeney, C.M., Brereton, C.F., Lavelle, E.C. and Mills, K.H.G, Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity., Immunity, 31, 2, 2009, 331-341 | en |
dc.identifier.other | Y | en |
dc.identifier.uri | http://hdl.handle.net/2262/67623 | |
dc.description | PUBLISHED | en |
dc.description | PMID: 19682929 | en |
dc.description.abstract | Th17 cells, CD4(+) T cells that secrete interleukin-17 (IL-17), are pathogenic in autoimmune diseases and their development and expansion is driven by the cytokines IL-6, TGF-beta, IL-21, IL-1, and IL-23. However, there are also innate sources of IL-17. Here, we show that gamma delta T cells express IL-23R and the transcription factor ROR gamma t and produce IL-17, IL-21, and IL-22 in response to IL-1 beta and IL-23, without T cell receptor engagement. IL-17-producing gamma delta T cells were found at high frequency in the brain of mice with experimental autoimmune encephalomyelitis (EAE). gamma delta T cells activated by IL-1 beta and IL-23 promoted IL-17 production by CD4(+) T cells and increased susceptibility to EAE, suggesting that gamma delta T cells act in an amplification loop for IL-1 7 production by Th17 cells. Our findings demonstrate that gamma delta T cells activated by IL-1 beta and IL-23 are an important source of innate IL-17 and IL-21 and provide an alternative mechanism whereby IL-1 and IL-23 may mediate autoimmune inflammation. | en |
dc.format.extent | 331-341 | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | Immunity | en |
dc.relation.ispartofseries | 31 | en |
dc.relation.ispartofseries | 2 | en |
dc.rights | Y | en |
dc.subject | CYTOKINE | en |
dc.subject | INFLAMMATION | en |
dc.subject | GROWTH-FACTOR-BETA | en |
dc.subject | PROINFLAMMATORY IL-17(+) | en |
dc.subject | MULTIPLE-SCLEROSIS | en |
dc.subject | T(H)17 CELLS | en |
dc.subject | TGF-BETA | en |
dc.title | Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity. | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/lavellee | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/millsk | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/lalorst | en |
dc.identifier.rssinternalid | 60701 | en |
dc.identifier.doi | http://dx.doi.org/10.1016/j.immuni.2009.08.001 | en |
dc.rights.ecaccessrights | OpenAccess | |
dc.subject.TCDTheme | Immunology, Inflammation & Infection | en |
dc.identifier.orcid_id | 0000-0002-3167-1080 | en |