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dc.contributor.authorBOWIE, ANDREWen
dc.date.accessioned2013-11-15T12:46:48Z
dc.date.available2013-11-15T12:46:48Z
dc.date.issued2010en
dc.date.submitted2010en
dc.identifier.citationUnterholzner, L., Keating, S.E., Baran, M., Horan, K.A., Jensen, S.B., Sharma, S., Sirois, C.M., (...), Bowie, A.G., IFI16 is an innate immune sensor for intracellular DNA, Nature Immunology, 11, 2010, 997-1004en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/67621
dc.descriptionPUBLISHEDen
dc.description.abstractThe detection of intracellular microbial DNA is critical to appropriate innate immune responses; however, knowledge of how such DNA is sensed is limited. Here we identify IFI16, a PYHIN protein, as an intracellular DNA sensor that mediates the induction of interferon-beta (IFN-beta). IFI16 directly associated with IFN-beta-inducing viral DNA motifs. STING, a critical mediator of IFN-beta responses to DNA, was recruited to IFI16 after DNA stimulation. Lowering the expression of IFI16 or its mouse ortholog p204 by RNA-mediated interference inhibited gene induction and activation of the transcription factors IRF3 and NF-kappa B induced by DNA and herpes simplex virus type 1 (HSV-1). IFI16 (p204) is the first PYHIN protein to our knowledge shown to be involved in IFN-beta induction. Thus, the PYHIN proteins IFI16 and AIM2 form a new family of innate DNA sensors we call 'AIM2-like receptors' (ALRs).en
dc.format.extent997-1004en
dc.language.isoenen
dc.relation.ispartofseriesNature Immunologyen
dc.relation.ispartofseries11en
dc.rightsYen
dc.subjectCYTOSOLIC DNAen
dc.subjectCYTOPLASMIC DNAen
dc.subjectI INTERFERONSen
dc.subjectIFN-BETAen
dc.titleIFI16 is an innate immune sensor for intracellular DNAen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/agbowieen
dc.identifier.rssinternalid69129en
dc.identifier.doihttp://dx.doi.org/10.1038/ni.1932en
dc.rights.ecaccessrightsOpenAccess
dc.subject.TCDThemeImmunology, Inflammation & Infectionen
dc.identifier.orcid_id0000-0001-5316-4373en


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