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dc.contributor.authorSENGE, MATHIAS
dc.date.accessioned2013-10-22T09:15:13Z
dc.date.available2013-10-22T09:15:13Z
dc.date.issued2011
dc.date.submitted2011en
dc.identifier.citationSergeeva, NN, Donnier-Marechal, M, Vaz, G, Davies, AM, Senge, MO, Synthesis and evaluation of the europium(III) and zinc(II) complexes as luminescent bioprobes in high content cell-imaging analysis, JOURNAL OF INORGANIC BIOCHEMISTRY, 105, 2011, 1589 - 1595en
dc.identifier.otherY
dc.identifier.urihttp://hdl.handle.net/2262/67524
dc.descriptionPUBLISHEDen
dc.description.abstractNovel phenanthroline derivatives and their europium(III) and zinc(II) complexes have been prepared in up to 92 %. In contrast to the stable zinc complexes, the europium compounds exhibit a strong luminescence in THF solution and complete dissociation of the complexes back to free ligands in DMSO. 1H NMR studies of the Eu(III)-complexes 5 and 6 also confirmed the existence of different states depending on the solvent used. Moreover, it was found that the compound 5 is stable in EtOH-PBS solutions; here a strong signal in the emission spectra corresponding to the europium ion was detected. These metal complexes can be used as fluorescence markers for the diagnosis of esophageal squamous carcinoma (OE21) cells at low concentrations. Cell images were acquired using the compound 5, 7-9 as luminescent markers. The first images were taken already after 20 min incubation time at a very low concentration range (0.7-1.6 ?M).en
dc.description.sponsorshipThis work was supported by funding from the Health Research Board (translational research award 2007 TRA/2007/11), Science Foundation Ireland (SFI P.I. 09/IN.1/B2650) and Fundac?o da Ciencia e Tecnologia.en
dc.format.extent1589en
dc.format.extent1595en
dc.language.isoenen
dc.relation.ispartofseriesJOURNAL OF INORGANIC BIOCHEMISTRY;
dc.relation.ispartofseries105;
dc.rightsYen
dc.subject.otherLuminescent bioprobes
dc.titleSynthesis and evaluation of the europium(III) and zinc(II) complexes as luminescent bioprobes in high content cell-imaging analysisen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/sengem
dc.identifier.rssinternalid77989
dc.rights.ecaccessrightsOpenAccess


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