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dc.contributor.authorFARES, MARIO ALI
dc.date.accessioned2013-09-02T11:40:46Z
dc.date.available2013-09-02T11:40:46Z
dc.date.issued2012
dc.date.submitted2012en
dc.identifier.citationRodrigo, G., Fares, M.A., Describing the structural robustness landscape of bacterial small RNAs, BMC Evolutionary Biology, 12, 1, 2012, art. no. 52en
dc.identifier.otherY
dc.identifier.urihttp://hdl.handle.net/2262/67298
dc.descriptionPUBLISHEDen
dc.description.abstractBackground: The potential role of RNA molecules as gene expression regulators has led to a new perspective on the intracellular control and genome organization. Because secondary structures are crucial for their regulatory role, we sought to investigate their robustness to mutations and environmental changes. Results: Here, we dissected the structural robustness landscape of the small non-coding RNAs (sncRNAs) encoded in the genome of the bacterium Escherichia coli . We found that bacterial sncRNAs are not significantly robust to both mutational and environmental perturbations when compared against artificial, unbiased sequences. However, we found that, on average, bacterial sncRNAs tend to be significantly plastic, and that mutational and environmental robustness strongly correlate. We further found that, on average, epistasis in bacterial sncRNAs is significantly antagonistic, and positively correlates with plasticity. Moreover, the evolution of robustness is likely dependent upon the environmental stability of the cell, with more fluctuating environments leading to the emergence and fixation of more robust molecules. Mutational robustness also appears to be correlated with structural functionality and complexity. Conclusion: Our study provides a deep characterization of the structural robustness landscape of bacterial sncRNAs, suggesting that evolvability could be evolved as a consequence of selection for more plastic molecules. It also supports that environmental fluctuations could promote mutational robustness. As a result, plasticity emerges to link robustness, functionality and evolvability.en
dc.description.sponsorshipWe thank S. F. Elena for useful comments. G.R. is supported by an EMBO long-term fellowship co-funded by Marie Curie actions (ALTF-1177-2011). M. A.F. is supported by the Spanish Ministerio de Ciencia e Inovacion grant BFU2009-12022.en
dc.format.extentart. no. 52en
dc.language.isoenen
dc.relation.ispartofseriesBMC Evolutionary Biology;
dc.relation.ispartofseries12;
dc.relation.ispartofseries1;
dc.rightsYen
dc.subjectEvolution, Evolvability, Plasticity, RNA structure, Robustness, Small RNA, Thermodynamicsen
dc.subject.lcshEvolution, Evolvability, Plasticity, RNA structure, Robustness, Small RNA, Thermodynamicsen
dc.titleDescribing the structural robustness landscape of bacterial small RNAsen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/faresm
dc.identifier.rssinternalid86524


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