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dc.contributor.authorFARES, MARIO ALI
dc.date.accessioned2013-09-02T11:27:52Z
dc.date.available2013-09-02T11:27:52Z
dc.date.issued2013
dc.date.submitted2013en
dc.identifier.citationFares, M.A., Keane, O.M., Toft, C., Carretero-Paulet, L., Jones, G.W., The Roles of Whole-Genome and Small-Scale Duplications in the Functional Specialization of Saccharomyces cerevisiae Genes, PLoS Genetics, 9, 1, 2013, art. no. e1003176en
dc.identifier.otherY
dc.identifier.urihttp://hdl.handle.net/2262/67295
dc.descriptionPUBLISHEDen
dc.description.abstractResearchers have long been enthralled with the idea that gene duplication can generate novel functions, crediting this process with great evolutionary importance. Empirical data shows that whole-genome duplications (WGDs) are more likely to be retained than small-scale duplications (SSDs), though their relative contribution to the functional fate of duplicates remains unexplored. Using the map of genetic interactions and the re-sequencing of 27 Saccharomyces cerevisiae genomes evolving for 2,200 generations we show that SSD-duplicates lead to neo-functionalization while WGD-duplicates partition ancestral functions. This conclusion is supported by: (a) SSD-duplicates establish more genetic interactions than singletons and WGD-duplicates; (b) SSD-duplicates copies share more interaction-partners than WGD-duplicates copies; (c) WGD-duplicates interaction partners are more functionally related than SSD-duplicates partners; (d) SSD-duplicates gene copies are more functionally divergent from one another, while keeping more overlapping functions, and diverge in their sub-cellular locations more than WGD-duplicates copies; and (e) SSD-duplicates complement their functions to a greater extent than WGD?duplicates. We propose a novel model that uncovers the complexity of evolution after gene duplication.en
dc.description.sponsorshipThis study was supported by Science Foundation Ireland grants to MAF under two programs: the President of Ireland Young Researcher Award (04/YI1/ M518) and the Research Frontiers Program (10/RFP/GEN2685). The study of distribution of mutations in duplicates and their possible effects on fitne ss was supported by a grant from the Ministerio de Ciencia e Innovacion (BFU2009-12022) to MAF. CT is supported by a long-term postdoctoral EMBO fellowship ( EMBO ALTF 730-2011). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscripten
dc.format.extentart. no. e1003176en
dc.language.isoenen
dc.relation.ispartofseriesPLoS Genetics;
dc.relation.ispartofseries9;
dc.relation.ispartofseries1;
dc.rightsYen
dc.subjectGene duplicationen
dc.subject.lcshGene duplicationen
dc.titleThe Roles of Whole-Genome and Small-Scale Duplications in the Functional Specialization of Saccharomyces cerevisiae Genesen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/faresm
dc.identifier.rssinternalid86520


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