dc.contributor.author | MORRIS, DEREK | |
dc.contributor.author | CORVIN, AIDEN PETER | |
dc.contributor.author | GILL, MICHAEL | |
dc.date.accessioned | 2013-08-07T15:14:43Z | |
dc.date.available | 2013-08-07T15:14:43Z | |
dc.date.issued | 2009 | |
dc.date.submitted | 2009 | en |
dc.identifier.citation | O'Donovan MC, Norton N, Williams H, Peirce T, Moskvina V, Nikolov I, Hamshere M, Carroll L, Georgieva L, Dwyer S, Holmans P, Marchini JL, Spencer CC, Howie B, Leung HT, Giegling I, Hartmann AM, Moller HJ, Morris DW, Shi Y, Feng G, Hoffmann P, Propping P, Vasilescu C, Maier W, Rietschel M, Zammit S, Schumacher J, Quinn EM, Schulze TG, Iwata N, Ikeda M, Darvasi A, Shifman S, He L, Duan J, Sanders AR, Levinson DF, Adolfsson R, Osby U, Terenius L, Jonsson EG, Cichon S, Nothen MM, Gill M, Corvin AP, Rujescu D, Gejman PV, Kirov G, Craddock N, Williams NM, Owen MJ., Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2., Molecular Psychiatry, 14, 1, 2009, 30 - 36 | en |
dc.identifier.other | Y | |
dc.identifier.uri | http://hdl.handle.net/2262/66908 | |
dc.description | PUBLISHED | en |
dc.description.abstract | We and others have previously reported linkage to schizophrenia on chromosome 10q25-q26 but,
to date, a susceptibility gene in the region has not been identified. We examined data from 3606
SNPs mapping to 10q25-q26 that had been typed in a genome-wide association study (GWAS) of
schizophrenia (479 UK cases/2937 controls). SNPs with p<0.01 (n=40) were genotyped in an
additional 163 UK cases and those markers that remained nominally significant at p<0.01 (n=22)
were genotyped in replication samples from Ireland, Germany and Bulgaria consisting of a total of
1664 cases with schizophrenia and 3541 controls. Only one SNP, rs17101921, was nominally
significant after meta-analyses across the replication samples and this was genotyped in an
additional six samples from the US/Australia, Germany, China, Japan, Israel and Sweden (n=
5142 cases/ 6561 controls). Across all replication samples, the allele at rs17101921 that was
associated in the GWAS showed evidence for association independent of the original data (OR
1.17 (95% CI 1.06-1.29), p=0.0009). The SNP maps 85kb from the nearest gene encoding
fibroblast growth factor receptor 2 (
FGFR2
) making this a potential susceptibility gene for
schizophrenia | en |
dc.description.sponsorship | This study makes use of data generated by the Wellcome Trust Case Control Consortium. A full list of the
investigators who contributed to the generation of the data is available from
www.wtccc.org.uk
. Funding for the
project was provided by the Wellcome Trust under award 076113. The UK research was supported by grants from
the MRC and the Wellcome Trust. In Dublin, the research was supported by Science Foundation Ireland, the Health
Research Board (Ireland), and the Wellcome Trust. We are grateful to Prof. John Waddington for sample
recruitment. Irish controls were supplied by Dr. Joe McPartlin and the Trinity College Biobank. In Bonn and
Mannheim, the work was supported by the National Genomic Network of the `Bundesministerium fur Bildung und
Forschung? (BMBF) and the Alfried Krupp von Bohlen und Halbach-Stiftung. We also thank the Department of
Psychiatry, LMU Munich for clinical characterization of the Munich subjects and the processing of the samples.
Recruitment in Munich was partially supported by GlaxoSmithKline. The Ashkenazi samples are part of the
Hebrew University Genetic Resource, HUGR (
www.hugr.org
) | en |
dc.format.extent | 30 | en |
dc.format.extent | 36 | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | Molecular Psychiatry; | |
dc.relation.ispartofseries | 14; | |
dc.relation.ispartofseries | 1; | |
dc.rights | Y | en |
dc.subject | FGFR2; schizophrenia; Genome Wide Association Study | en |
dc.subject.lcsh | FGFR2; schizophrenia; Genome Wide Association Study | en |
dc.title | Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2. | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/acorvin | |
dc.identifier.peoplefinderurl | http://people.tcd.ie/morrisdw | |
dc.identifier.peoplefinderurl | http://people.tcd.ie/mgill | |
dc.identifier.rssinternalid | 53127 | |
dc.identifier.rssuri | http://www.nature.com/mp/journal/vaop/ncurrent/pdf/mp2008108a.pdf | en |