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dc.contributor.authorMORRIS, DEREK
dc.contributor.authorCORVIN, AIDEN PETER
dc.contributor.authorGILL, MICHAEL
dc.date.accessioned2013-08-07T15:14:43Z
dc.date.available2013-08-07T15:14:43Z
dc.date.issued2009
dc.date.submitted2009en
dc.identifier.citationO'Donovan MC, Norton N, Williams H, Peirce T, Moskvina V, Nikolov I, Hamshere M, Carroll L, Georgieva L, Dwyer S, Holmans P, Marchini JL, Spencer CC, Howie B, Leung HT, Giegling I, Hartmann AM, Moller HJ, Morris DW, Shi Y, Feng G, Hoffmann P, Propping P, Vasilescu C, Maier W, Rietschel M, Zammit S, Schumacher J, Quinn EM, Schulze TG, Iwata N, Ikeda M, Darvasi A, Shifman S, He L, Duan J, Sanders AR, Levinson DF, Adolfsson R, Osby U, Terenius L, Jonsson EG, Cichon S, Nothen MM, Gill M, Corvin AP, Rujescu D, Gejman PV, Kirov G, Craddock N, Williams NM, Owen MJ., Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2., Molecular Psychiatry, 14, 1, 2009, 30 - 36en
dc.identifier.otherY
dc.identifier.urihttp://hdl.handle.net/2262/66908
dc.descriptionPUBLISHEDen
dc.description.abstractWe and others have previously reported linkage to schizophrenia on chromosome 10q25-q26 but, to date, a susceptibility gene in the region has not been identified. We examined data from 3606 SNPs mapping to 10q25-q26 that had been typed in a genome-wide association study (GWAS) of schizophrenia (479 UK cases/2937 controls). SNPs with p<0.01 (n=40) were genotyped in an additional 163 UK cases and those markers that remained nominally significant at p<0.01 (n=22) were genotyped in replication samples from Ireland, Germany and Bulgaria consisting of a total of 1664 cases with schizophrenia and 3541 controls. Only one SNP, rs17101921, was nominally significant after meta-analyses across the replication samples and this was genotyped in an additional six samples from the US/Australia, Germany, China, Japan, Israel and Sweden (n= 5142 cases/ 6561 controls). Across all replication samples, the allele at rs17101921 that was associated in the GWAS showed evidence for association independent of the original data (OR 1.17 (95% CI 1.06-1.29), p=0.0009). The SNP maps 85kb from the nearest gene encoding fibroblast growth factor receptor 2 ( FGFR2 ) making this a potential susceptibility gene for schizophreniaen
dc.description.sponsorshipThis study makes use of data generated by the Wellcome Trust Case Control Consortium. A full list of the investigators who contributed to the generation of the data is available from www.wtccc.org.uk . Funding for the project was provided by the Wellcome Trust under award 076113. The UK research was supported by grants from the MRC and the Wellcome Trust. In Dublin, the research was supported by Science Foundation Ireland, the Health Research Board (Ireland), and the Wellcome Trust. We are grateful to Prof. John Waddington for sample recruitment. Irish controls were supplied by Dr. Joe McPartlin and the Trinity College Biobank. In Bonn and Mannheim, the work was supported by the National Genomic Network of the `Bundesministerium fur Bildung und Forschung? (BMBF) and the Alfried Krupp von Bohlen und Halbach-Stiftung. We also thank the Department of Psychiatry, LMU Munich for clinical characterization of the Munich subjects and the processing of the samples. Recruitment in Munich was partially supported by GlaxoSmithKline. The Ashkenazi samples are part of the Hebrew University Genetic Resource, HUGR ( www.hugr.org )en
dc.format.extent30en
dc.format.extent36en
dc.language.isoenen
dc.relation.ispartofseriesMolecular Psychiatry;
dc.relation.ispartofseries14;
dc.relation.ispartofseries1;
dc.rightsYen
dc.subjectFGFR2; schizophrenia; Genome Wide Association Studyen
dc.subject.lcshFGFR2; schizophrenia; Genome Wide Association Studyen
dc.titleAnalysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2.en
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/acorvin
dc.identifier.peoplefinderurlhttp://people.tcd.ie/morrisdw
dc.identifier.peoplefinderurlhttp://people.tcd.ie/mgill
dc.identifier.rssinternalid53127
dc.identifier.rssurihttp://www.nature.com/mp/journal/vaop/ncurrent/pdf/mp2008108a.pdfen


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